Association between C3435T polymorphism and methotrexate treatment outcomes in rheumatoid arthritis patients: a meta-analysis.

Authors:
Xiao He
Xiao He
Institute of High Energy Physics
China
Mingfang Sun
Mingfang Sun
The First Affiliated Hospital of Chongqing Medical University
Chongqing | China
Mengshan Li
Mengshan Li
College of Physics and Electronic Information
Liangliang Li
Liangliang Li
Université Laval
Canada
Yi Yang
Yi Yang
Institute of Bioengineering and Nanotechnology
Singapore | Singapore

Pharmacogenomics 2019 Apr 15;20(5):381-392. Epub 2019 Apr 15.

Department of Rheumatology & Clinical Immunology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing 400042, PR China.

This study was conducted to investigate the relationship between gene C3435T polymorphism and methotrexate treatment outcomes in rheumatoid arthritis patients. Seven electronic databases (PubMed, EMBASE, Web of Science, Cochrane, OVID, Chinese biomedical literature [CBM], China National Knowledge Infrastructure [CNKI] and Wanfang databases) were searched to select eligible publications until 18 July 2018. The references of relevant articles were also manually searched. The quality evaluation of the included studies was carried out according to the guidelines of the Newcastle-Ottawa Scale. Data were analyzed with Review Manager 5.3 and Stata 13.0 software. In total, 12 articles involving 2014 patients were included. Our results demonstrated that the gene C3435T polymorphism might be a reliable predictor of response to methotrexate in rheumatoid arthritis patients. However, well-designed, multicenter and large-scale prospective studies are required to further confirm the validity of our results.

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs-2018-0172DOI Listing
April 2019
1 Read

Publication Analysis

Top Keywords

c3435t polymorphism
12
rheumatoid arthritis
12
arthritis patients
12
treatment outcomes
8
outcomes rheumatoid
8
methotrexate treatment
8
gene c3435t
8
polymorphism methotrexate
8
evaluation included
4
included studies
4
quality evaluation
4
searched quality
4
manually searched
4
studies carried
4
carried guidelines
4
data analyzed
4
scale data
4
newcastle-ottawa scale
4
guidelines newcastle-ottawa
4
articles manually
4

References

(Supplied by CrossRef)
Article in Acta Med. Litu.
Stropuviene S et al.
Acta Med. Litu. 2018

The National Collaborating Centre for Chronic Conditions et al.
2018
Article in Am. Fam. Physician
Wasserman AM et al.
Am. Fam. Physician 2011
Article in Clin. Exp. Rheumatol.
Pablos JL et al.
Clin. Exp. Rheumatol. 2018

Similar Publications