Synthesis and biological evaluation of (±)-hippolachnin and analogs.

J Antibiot (Tokyo) 2019 06 12;72(6):375-383. Epub 2019 Apr 12.

Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany.

Due its unique structure and its reported potent antifungal activity, the marine polyketide hippolachnin A (1) has attracted much attention in the synthetic community. Herein, we describe the development of a concise, diversifiable and scalable synthesis of the racemic natural product, which serves as a platform for the generation of bioactive analogues. Biological testing of our synthetic material did not confirm the reported antifungal activity of hippolachnin A but unraveled moderate activity against nematodes and microbes.

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Source
http://www.nature.com/articles/s41429-019-0176-x
Publisher Site
http://dx.doi.org/10.1038/s41429-019-0176-xDOI Listing
June 2019
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