Mechanisms of natural resistance of Balb/c mice to experimental liver amoebiasis.

Authors:
Mario Nequiz
Mario Nequiz
National Autonomous University of México Medical School
Mexico
Sergio Enriquez-Flores
Sergio Enriquez-Flores
Laboratorio de Bioquímica-Genética y Dirección de Investigación
Mexico
Emma Saavedra
Emma Saavedra
Departamento de Bioquímica

Biosci Rep 2019 May 3;39(5). Epub 2019 May 3.

Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 04510, México

is the parasite responsible for human amoebiasis. The analysis of the natural resistance mechanisms of some rodents to amoebic liver abscess (ALA) may reveal alternative pathogenicity mechanisms to those previously discovered in the experimental model of ALA in hamsters. In this work the natural resistance of BALB/c mice to ALA was explored by performing: (i) chemotaxis analysis with a specifically designed chamber; (ii) amoebic survival in fresh and decomplemented serum; (iii) histological temporal course analysis of ALA development in mice with different treatments (hypocomplementemic, hyperimmune and treated with iNOS and NADPH oxidase inhibitors) and (iv) mouse liver amoebic infection by both implantation of ALA from hamsters and inoculation of parasites into the peritoneal cavity. The results show that clearance from the mouse liver is related to a low chemotactic activity of complement, which results in poor inflammatory response and parasite inability to cause tissue damage. Also, the absence of amoebic tropism for the mouse liver is correlated with resistance to experimental liver amoebiasis.

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http://bioscirep.org/lookup/doi/10.1042/BSR20182333
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http://dx.doi.org/10.1042/BSR20182333DOI Listing
May 2019
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References

(Supplied by CrossRef)
Amoebiasis
World Health Organization et al.
WHO Weekly Epidemiologic Record 1997

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