A Nanocomposite Based on Reduced Graphene and Gold Nanoparticles for Highly Sensitive Electrochemical Detection of through Its Virulence Factors.

Authors:
Islem Gandouzi
Islem Gandouzi
Iuliu Haţieganu University of Medicine and Pharmacy
Mihaela Tertis
Mihaela Tertis
Iuliu Haţieganu University of Medicine and Pharmacy
Andreea Cernat
Andreea Cernat
Iuliu Haţieganu University of Medicine and Pharmacy
Dalila Saidane-Mosbahi
Dalila Saidane-Mosbahi
Université Laval
Canada
Aranka Ilea
Aranka Ilea
"Iuliu Haţieganu" University of Medicine and Pharmacy
Romania
Cecilia Cristea
Cecilia Cristea
Iuliu Haţieganu University of Medicine and Pharmacy
Cluj-Napoca | Romania

Materials (Basel) 2019 Apr 11;12(7). Epub 2019 Apr 11.

Analytical Chemistry Department, Faculty of Pharmacy, Iuliu Haţieganu University of Medicine and Pharmacy, 4 Louis Pasteur St., 400349 Cluj-Napoca, Romania.

Pyoverdine is a fluorescent siderophore produced by that can be considered as a detectable marker in nosocomial infections. The presence of pyoverdine in water can be directly linked to the presence of the , thus being a nontoxic and low-cost marker for the detection of biological contamination. A novel platform was developed and applied for the electrochemical selective and sensitive detection of pyoverdine, based on a graphene/graphite-modified screen-printed electrode (SPE) that was electrochemically reduced and decorated with gold nanoparticles (NPs). The optimized sensor presenting higher sensitivity towards pyoverdine was successfully applied for its detection in real samples (serum, saliva, and tap water), in the presence of various interfering species. The excellent analytical performances underline the premises for an early diagnosis kit of bacterial infections based on electrochemical sensors.

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Source
http://dx.doi.org/10.3390/ma12071180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480001PMC
April 2019
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References

(Supplied by CrossRef)
Electrochemical medical biosensors for POC applications
Anik et al.
2017

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