Identification of influenza C virus in young South Korean children, from October 2013 to September 2016.

Authors:
Han Sol Lee
Han Sol Lee
Sungkyunkwan University
Sooyeon Lim
Sooyeon Lim
Seoul National University
Ji Yun Noh
Ji Yun Noh
Korea University College of Medicine
Joon Young Song
Joon Young Song
Korea University College of Medicine
South Korea
Hee Jin Cheong
Hee Jin Cheong
Korea University College of Medicine
South Korea
Jung Hwa Lee
Jung Hwa Lee
Center for Environmental Health Sciences
Oakland | United States
Sung Il Woo
Sung Il Woo
Inha University College of Medicine
Woo Joo Kim
Woo Joo Kim
Korea University College of Medicine
South Korea

J Clin Virol 2019 Jun 27;115:47-52. Epub 2019 Mar 27.

Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea; Asia Pacific Influenza Institute, Korea University College of Medicine, Seoul, South Korea. Electronic address:

Background: Influenza C virus has been largely neglected, compared to influenza A orB viruses, and is not routinely tested in clinical practices. However, several studies have indicated that influenza C virus causes severe acute respiratory illness and pneumonia in all ages.

Objective: We conducted a study to identify influenza C virus among young children in South Korea.

Study Design: From October 2013 to September 2016, 973 young children with influenzalike illness (ILI) were enrolled at three university hospitals. We tested nasopharyngeal samples for 16 types of respiratory viruses. Among the tested samples, 564 were positive for one or more respiratory viruses. Except for the samples where 16 types of respiratory viruses were found, 409 negative samples were examined for the presence of influenza C virus, using a matrix gene specific primer set.

Results: Among 409 nasopharyngeal samples, five influenza C viruses were detected. The manifestation of influenza C virus infection in young children was observed acute respiratory illness, such as fever, rhinorrhea, and cough, but no pneumonia or severe respiratory illness. Nucleotide sequencing was conducted and a phylogenetic tree was generated. We found that C/Sao Paulo/387/82-like lineage viruses circulated in South Korea, and the fully sequenced virus (C/Seoul/APD462/2015) was closely related to C/Victoria/2/2012 and C/Tokyo/4/2014 strains.

Conclusions: This study was the first report of influenza C virus detection in South Korea. Although severe illness was not observed in this study, we suggest the necessity for influenza C virus testing in pediatric patients with ILI, considering other reports of severe illnesses caused by influenza C virus infections.

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13866532193007
Publisher Site
http://dx.doi.org/10.1016/j.jcv.2019.03.016DOI Listing
June 2019
7 Reads

Publication Analysis

Top Keywords

influenza virus
36
respiratory illness
12
young children
12
respiratory viruses
12
virus
10
influenza
10
2013 september
8
south korea
8
october 2013
8
september 2016
8
samples types
8
acute respiratory
8
types respiratory
8
virus young
8
nasopharyngeal samples
8
viruses
6
respiratory
6
samples
5
illness
5
detected manifestation
4

Similar Publications