Lung Eosinophils - a Novel 'Virus Sink' that is Defective in Asthma?

Authors:
Milos Jesenak
Milos Jesenak
Comenius University in Bratislava
Slovakia
Jurgen Schwarze
Jurgen Schwarze
Imperial College London
United Kingdom

Allergy 2019 Apr 10. Epub 2019 Apr 10.

Child Life and Health and Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.

Eosinophils represent one of the most studied cells in the development and pathophysiology of various immune mediated disorders and conditions. Moreover, they serve as important biomarkers (diagnostic, therapy-driving, prognostic) in daily allergy praxis and can be affected by several therapeutic interventions. Eosinophils differentiate from a pluripotent progenitor under the influence of several cytokines and growth factors. Amongst these, interleukin-5 (IL-5) seems to be critical for eosinophil differentiation and maturation in the bone marrow. After reaching maturity, eosinophils enter the circulation and in response to stimuli such as eotaxins, they migrate into the tissues. This article is protected by copyright. All rights reserved.

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http://dx.doi.org/10.1111/all.13811DOI Listing
April 2019
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