A Pediatric Case of Transformed Mycosis Fungoides in a BRCA2 Positive Patient.

Authors:
Joyce Turner
Joyce Turner
National Human Genome Research Institute
United States
Miriam Bornhorst
Miriam Bornhorst
University of Michigan Medical School
Shana S Jacobs
Shana S Jacobs
Children's National Medical Center
Washington | United States
Kirsten M Williams
Kirsten M Williams
National Cancer Institute
United States

J Pediatr Hematol Oncol 2019 Apr 8. Epub 2019 Apr 8.

Children's National Medical Center, Washington, DC.

Cutaneous T-cell lymphomas are very rare in children. Although mycosis fungoides is the most common of these rare cutaneous T-cell lymphomas in children, transformation to an aggressive malignancy remains extremely uncommon, and there are no clear guidelines for clinical management in the pediatric population. In addition, the increased usage of next-generation sequencing for pediatric patients with unusual malignancies may result in the discovery of pathogenic germline mutations, though the association between these mutations and the patient's cancer is not always clear. We present here a unique pediatric case of transformed mycosis fungoides in a patient with BRCA2 mutation.

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Source
http://dx.doi.org/10.1097/MPH.0000000000001481DOI Listing
April 2019
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