Family history of cancer and risk of paediatric and young adult's testicular cancer: A Norwegian cohort study.

Authors:
Ellen Ruud
Ellen Ruud
Norway. ellen.ruud@rikshospitalet.no
Norway
Hege S Haugnes
Hege S Haugnes
University Hospital of North Norway
Norway
Magne Thoresen
Magne Thoresen
University of Oslo
Per Nafstad
Per Nafstad
Norwegian Institute of Public Health
Norway
Ljiljana Vlatkovic
Ljiljana Vlatkovic
The Norwegian Radium Hospital
Oslo | Norway
Karl Gerhard Blaasaas
Karl Gerhard Blaasaas
Finance Norway

Br J Cancer 2019 May 10;120(10):1007-1014. Epub 2019 Apr 10.

Institute of Health and Society, University of Oslo, P.O Box 1130 Blindervn, 0318, Oslo, Norway.

Background: The aim of this study was to examine the association of a family history of cancer with the risk of testicular cancer in young adults.

Methods: This is a prospective cohort study including 1,974,287 males born 1951-2015, of whom 2686 were diagnosed with TC before the age of 30.

Results: A history of TC in male relatives was significantly associated with a diagnosis of TC among children and young adults, including brothers (6.3-fold), sons (4.7-fold), fathers (4.4-fold), paternal uncles (2.0-fold) and maternal uncles (1.9-fold). Individuals with a father diagnosed with a carcinoma or sarcoma showed an elevated risk (1.1-fold and 1.8-fold, respectively). A family history of mesothelioma was positively associated with a risk of TC [(father (2.8-fold), mother (4.6-fold) and maternal uncles and aunt (4.4-fold)]. Elevated risks were also observed when siblings were diagnosed with malignant melanoma (1.4-fold). The risk of TC was also increased when fathers (11.1-fold), paternal (4.9-fold) and maternal uncles and aunts (4.6-fold) were diagnosed with malignant neuroepithelial-tumours.

Conclusion: We found an increased risk of TC among children and young adults with a family history of TC, carcinoma, mesothelioma, sarcoma, malignant melanoma and malignant neuroepithelial tumours. Hereditary cancer syndromes might underlie some of the associations reported in this study.

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41416-019-0445-2DOI Listing
May 2019
5 Reads

Publication Analysis

Top Keywords

family history
16
maternal uncles
12
malignant melanoma
8
diagnosed malignant
8
testicular cancer
8
young adults
8
children young
8
cohort study
8
history cancer
8
cancer risk
8
risk
6
cancer
5
uncles 19-fold
4
malignant neuroepithelial-tumoursconclusion
4
family
4
uncles 20-fold
4
20-fold maternal
4
19-fold individuals
4
father diagnosed
4
sarcoma elevated
4

References

(Supplied by CrossRef)
Article in Eur. Urol.
A Rosen et al.
Eur. Urol. 2011
Article in Int. J. Androl.
R Jacobsen et al.
Int. J. Androl. 2006
Article in Histopathology
SR Williamson et al.
Histopathology 2017
Article in Physiol. Rev.
NE Skakkebaek et al.
Physiol. Rev. 2016
Article in Br. J. Cancer
D Forman et al.
Br. J. Cancer 1992
Article in Br. J. Cancer
K Heimdal et al.
Br. J. Cancer 1996
Article in Urology
JR Spermon et al.
Urology 2001
Article in Int. J. Cancer
RB Nordsborg et al.
Int. J. Cancer 2011
Article in Eur. Urol.
E Kharazmi et al.
Eur. Urol. 2015
Article in Hum. Reprod. Update
JP Bonde et al.
Hum. Reprod. Update 2016
Article in Int. J. Cancer
E Pukkala et al.
Int. J. Cancer 2002

Similar Publications