Fatal necrotizing esophagitis in a patient with leukocytoclastic cutaneous vasculitis and ankylosing spondylitis.

Authors:
Aloisio Felipe-Silva
Aloisio Felipe-Silva
National Institutes of Health
United States
Marcia Yoshie Kanegae
Marcia Yoshie Kanegae
Internal Medicine Division - Hospital Universitário - Universidade de São Paulo

Autops Case Rep 2019 Apr-Jun;9(2):e2018070. Epub 2019 Mar 22.

Universidade de São Paulo (USP), Hospital Universitário, Internal Medicine Division. São Paulo, SP, Brazil.

Esophageal infection by spp. is a common opportunistic entity in immunocompromised hosts; however, systemic fungal dissemination due to perforation or transmural necrosis, also known as necrotizing esophagitis (NCE), is rare. We report the case of a 61-year-old male patient with diagnosed ankylosing spondylitis, severe arteriosclerosis, and vasculitis under immunosuppressive therapy who presented NCE with fungal and bacterial septicemia diagnosed at autopsy. Necrotizing esophagitis is a rare manifestation of infection, which may be a final complication in severely ill patients. Unfortunately, it may be underdiagnosed, and we call attention to this devastating complication in patients with leukocytoclastic cutaneous vasculitis and ankylosing spondylitis.

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Source
http://www.autopsyandcasereports.org/article/doi/10.4322/acr
Publisher Site
http://dx.doi.org/10.4322/acr.2018.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433139PMC
March 2019
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