A step beyond the hygiene hypothesis-immune-mediated classes determined in a population-based study.

Authors:
Vladeta Ajdacic-Gross
Vladeta Ajdacic-Gross
University of Zurich
Switzerland
Margot Mutsch
Margot Mutsch
World Health Organization Collaborating Centre for Travelers' Health
Stephanie Rodgers
Stephanie Rodgers
Zurich University Hospital of Psychiatry
Switzerland
Erich Seifritz
Erich Seifritz
University Hospital of Psychiatry
Switzerland

BMC Med 2019 Apr 9;17(1):75. Epub 2019 Apr 9.

Department of Psychiatry, Center for Research in Psychiatric Epidemiology and Psychopathology, Lausanne University Hospital, Prilly, Switzerland.

Background: Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions. The aim of this study was to make a step beyond the hygiene hypothesis and to comprehensively classify these patterns with latent class analysis (LCA). A second aim was to characterize the classes by associations with immunological, clinical, and sociodemographic variables.

Methods: LCA was applied to data from the CoLaus|PsyCoLaus study (N = 4874, age range 35-82 years) separately for men and women. It was based on survey information on chickenpox, measles, mumps, rubella, herpes simplex, pertussis, scarlet fever, hay fever, asthma, eczema, urticaria, drug allergy, interparental violence, parental maltreatment, and trauma in early childhood. Subsequently, we examined how immune-mediated classes were reflected in leukocyte counts, inflammatory markers (IL-1β, IL-6, TNF-α, hsCRP), chronic inflammatory diseases, and mental disorders, and how they differed across social classes and birth cohorts.

Results: LCA results with five classes were selected for further analysis. Latent classes were similar in both sexes and were labeled according to their associations as neutral, resilient, atopic, mixed (comprising infectious and atopic diseases), and ACE class. They came across with specific differences in biomarker levels. Mental disorders typically displayed increased lifetime prevalence rates in the atopic, the mixed, and the ACE classes, and decreased rates in the resilient class. The same patterns were apparent in chronic inflammatory diseases, except that the ACE class was relevant specifically in women but not in men.

Conclusions: This is the first study to systematically determine immune-mediated classes that evolve early in life. They display characteristic associations with biomarker levels and somatic and psychiatric diseases occurring later in life. Moreover, they show different distributions across social classes and allow to better understand the mechanisms beyond the changes in the prevalence of chronic somatic and psychiatric diseases.

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12916-019-1311-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454751PMC
April 2019
2 Reads
7.249 Impact Factor

Article Mentions


Provided by Crossref Event Data

Publication Analysis

Top Keywords

classes
9
diseases ace
8
biomarker levels
8
atopic diseases
8
somatic psychiatric
8
atopic mixed
8
mental disorders
8
immune-mediated classes
8
chronic inflammatory
8
inflammatory diseases
8
psychiatric diseases
8
social classes
8
ace class
8
step hygiene
8
diseases
6
prevalence chronic
4
diseases mental
4
changes prevalence
4
disorders differed
4
chronic somatic
4

References

(Supplied by CrossRef)
Article in N Engl J Med
AL Barabasi et al.
N Engl J Med 2007
Article in Front Neuroendocrinol
SD Bilbo et al.
Front Neuroendocrinol 2012
Article in J Immunol
N Torow et al.
J Immunol 2017
Article in Brain Research
Graham A.W. Rook et al.
Brain Research 2015
Article in Perspect Public Health
SF Bloomfield et al.
Perspect Public Health 2016
Article in Allergol Int
PI Pfefferle et al.
Allergol Int 2014
Article in J Allergy Clin Immunol
J Penders et al.
J Allergy Clin Immunol 2013
Article in Semin Fetal Neonatal Med
M Wang et al.
Semin Fetal Neonatal Med 2016
Article in Evol Med Public Health.
GA Rook et al.
Evol Med Public Health. 2013
Article in Arch Gen Psychiatry
KA McLaughlin et al.
Arch Gen Psychiatry 2010
Article in Arch Gen Psychiatry
JG Green et al.
Arch Gen Psychiatry 2010

Similar Publications