Amplifying the concept of psoriatic arthritis: The role of autoimmunity in systemic psoriatic disease.

Authors:
Maria Sole Chimenti
Maria Sole Chimenti
University of Rome Tor Vergata
Italy
Francesco Caso
Francesco Caso
Department of Clinical and Experimental Medicine
Italy
Stefano Alivernini
Stefano Alivernini
Catholic University of the Sacred Heart
Italy
Luisa Costa
Luisa Costa
University Federico II
Napoli | Italy
Barbara Tolusso
Barbara Tolusso
Institute of Rheumatology
United Kingdom
Paola Triggianese
Paola Triggianese
Allergology and Clinical Immunology
Paola Conigliaro
Paola Conigliaro
University of Glasgow
United Kingdom

Autoimmun Rev 2019 Jun 5;18(6):565-575. Epub 2019 Apr 5.

Rheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis that may be present in near 30% of patients affected by psoriasis (PsO), clinically characterized by inflammation of periarticular (e.g., enthesis) and articular structures. Recently, an autoimmune footprint of PsA pathogenesis has been demonstrated with the presence of autoantigens and related autoantibodies in PsA patients' sera. In this context, histological features of PsA synovitis supports the relevance of an autoimmune pathogenesis of the disease. Since there is no currently validated test for PsA, the analysis of PsA synovial tissue revealed pathognomonic characteristics of PsA that may support the clinician in the clinical practice. PsA synovitis is characterized by a sublining infiltrate with T and B cells, vascular proliferation and a relative thin lining layer of proliferating intimal synoviocytes. PsA synovial histopathology shows that ectopic lymphoid-neogenesis with an increase of IL-23 expression. These new pathogenetics features and the systemic nature of the disease raised the concept of a Systemic Psoriatic Disease (SysPsD), characterized by multiple extra-cutaneous and -articular manifestations, highlightening the great heterogeneity of this condition. SyPsD represents a heterogeneous chronic inflammatory condition with a wide spectrum of phenotypical manifestations. The purpose of this review is to describe the new pathogenetic mechanisms and the different clinical pictures of SysPsD, with the ultimate goal of improving the knowledge of this heterogeneous chronic inflammatory condition.

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Source
https://linkinghub.elsevier.com/retrieve/pii/S15689972193008
Publisher Site
http://dx.doi.org/10.1016/j.autrev.2018.11.007DOI Listing
June 2019
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