A Novel Traditional Chinese Medicine ameliorates fatigue-induced cardiac hypertrophy and dysfunction via regulation of energy metabolism.

Authors:
Rong Huang
Rong Huang
State Key Laboratory of Freshwater Ecology and Biotechnology
China
Xiao-Hong Wei
Xiao-Hong Wei
Peking University Health Science Center
China
Chun-Shui Pan
Chun-Shui Pan
Peking University First Hospital
China
Quan Li
Quan Li
The Chinese University of Hong Kong
Hong Kong
Shu-Ya He
Shu-Ya He
Nanhua University
China
Jing-Yu Fan
Jing-Yu Fan
Peking University Health Science Center
China
Jing-Yan Han
Jing-Yan Han
Peking University Health Science Center
China

Am J Physiol Heart Circ Physiol 2019 Apr 5. Epub 2019 Apr 5.

Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, China.

Aims:Prolonged exercise and exercise training can adversely affect cardiac function in some individuals. QiShenYiQi Pills® (QSYQ), a compound Chinese medicine,has been previously shown to improve pressure overload-induced cardiac hypertrophy. We hypothesized that QSYQ can ameliorate as well the fatigue-induced cardiac hypertrophy. This study was to test this hypothesis and underlying mechanism with focusing on its role in energy regulation. Methods:Male Sprague-Dawley rats were used to establish exercise adaption and fatigue model on a motorized rodent treadmill. Echocardiographic analysis and heart function test were performed to assess heart systolic function. Food-Intake Weight/Body Weight, Heart Weight/Body Weightwere assessed, hematoxylin and eosin staining, and immunofluorescence staining of myocardium sections were performed. ATP synthase expression and activity, ATP, ADP and AMP levels were assessed using Western blotand ELISA. Expression of proteins related to energy metabolism and IGF-1R signaling was determined using Western blot. Results:QSYQ attenuated Food-Intake Weight/Body Weight decrease, improved myocardial structure and heart function, restored the expression and distribution of myocardial cx43 after fatigue, concomitant with an increased ATP production and a restoration of metabolism-related proteins expression. QSYQ upgraded the expression of IGF-1R, P-AMPK/AMPK, PGC-1α, Nrf1, P-PI3K/PI3K and P-Akt/Akt thereby attenuated the dysregulation of IGF-1R signaling after fatigue. Conclusion:QSYQ relieved fatigue-induced cardiac hypertrophy and enhanced heart function, which is correlated to its potential to improve energy metabolism by regulating IGF-1R signaling.

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Source
http://dx.doi.org/10.1152/ajpheart.00731.2018DOI Listing
April 2019
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