Heart rate fragmentation: using cardiac pacemaker dynamics to probe the pace of biological aging.

Authors:
Madalena D Costa
Madalena D Costa
Harvard Medical School
Israel
Ary L Goldberger
Ary L Goldberger
Harvard Medical School
United States

Am J Physiol Heart Circ Physiol 2019 Jun 5;316(6):H1341-H1344. Epub 2019 Apr 5.

Department of Medicine, Margret and H. A. Rey Institute for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, Massachusetts.

This perspectives article discusses the use of a novel set of dynamical biomarkers in the assessment of biological versus chronological age. The basis for this development is a recently delineated property of altered sinoatrial pacemaker-neuroautonomic function, termed heart rate fragmentation (HRF). Fragmented rhythms manifest as an increase in the density of changes in heart rate acceleration sign, not mechanistically explicable by physiological cardiac vagal tone modulation. We reported that HRF increased monotonically with cross-sectional age and that HRF measures, but not conventional heart rate variability metrics, were significantly associated with major incident cardiovascular events in the Multi-Ethnic Study of Atherosclerosis (MESA). Furthermore, HRF measures added value to both Framingham and MESA cardiovascular risk indices. Here, we propose that interventions that fundamentally slow or reverse the pace of biological aging, via system-wide effects, should be associated with a decrease in the degree of HRF and possibly with a reemergence of the nonfragmented ("fluent") patterns associated with more youthful heart rate dynamics.

Download full-text PDF

Source
https://www.physiology.org/doi/10.1152/ajpheart.00110.2019
Publisher Site
http://dx.doi.org/10.1152/ajpheart.00110.2019DOI Listing
June 2019
5 Reads

Publication Analysis

Top Keywords

heart rate
20
hrf measures
8
pace biological
8
biological aging
8
rate fragmentation
8
heart
5
hrf
5
manifest increase
4
measures conventional
4
cross-sectional age
4
increased monotonically
4
monotonically cross-sectional
4
age hrf
4
conventional heart
4
major incident
4
incident cardiovascular
4
associated major
4
metrics associated
4
rate variability
4
variability metrics
4

References

(Supplied by CrossRef)

Similar Publications