Effect of Pulsed and Continuous Ultrasound Therapy on the Degree of Collateral Axonal Branching at the Lesion Site, Polyinnervation of Motor End Plates, and Recovery of Motor Function after Facial Nerve Reconstruction.

Umut Ozsoy, Eren Ogut, Rahime Sekerci, Arzu Hizay, Svenja Rink, Doychin N Angelov

Overview

The aim of the present study is to test whether ultrasound therapy of muscles denervated by nerve injury would improve the quality of their reinnervation by reduction of the collateral axonal branching at the lesion site and poly?innervation degree at the neuromuscular junctions. After transection and suture of the buccal branch of the facial nerve, pulsed or continuous type of ultrasound therapy was applied to the paralyzed whisker pad muscles of rats in the course of 2?months. Instead of reduction, we found a significant increase in the collateral axonal branching after continuous ultrasound therapy when compared to the branching determined after pulsed or sham ultrasound therapy. Both types of ultrasound therapy also failed to reduce the proportion of polyinnervated end plates in the reinnervated facial muscles. Accordingly, continuous ultrasound therapy failed to restore any parameter of the motor performance of the vibrissal hairs.

Summary

Application of pulsed ultrasound therapy promoted slight improvements of the functional parameters angular velocity and acceleration.

Author Comments

Dr.  erenogut, PhD
Dr. erenogut, PhD
Department of Anatomy / Bahcesehir University School of Medicine
Asst. Prof.
Anatomy
Istanbul | Turkey
The inhomogeneous structural and functional results achieved after both types of ultrasound therapy let us conclude that further studies are required to evaluate its effects on peripheral nerve regeneration.Dr. erenogut, PhD

Resources

Effect of Pulsed and Continuous Ultrasound Therapy on the Degree of Collateral Axonal Branching at the Lesion Site, Polyinnervation of Motor End Plates, and Recovery of Motor Function after Facial Nerve Reconstruction.

Authors:
Dr.  erenogut, PhD
Dr. erenogut, PhD
Department of Anatomy / Bahcesehir University School of Medicine
Asst. Prof.
Anatomy
Istanbul | Turkey

Anat Rec (Hoboken) 2019 08 23;302(8):1314-1324. Epub 2019 Apr 23.

Anatomical Institute I, University of Cologne, Cologne, Germany.

The aim of the present study is to test whether ultrasound therapy of muscles denervated by nerve injury would improve the quality of their reinnervation by reduction of the collateral axonal branching at the lesion site and poly-innervation degree at the neuromuscular junctions. After transection and suture of the buccal branch of the facial nerve, pulsed or continuous type of ultrasound therapy was applied to the paralyzed whisker pad muscles of rats in the course of 2?months. Instead of reduction, we found a significant increase in the collateral axonal branching after continuous ultrasound therapy when compared to the branching determined after pulsed or sham ultrasound therapy. Both types of ultrasound therapy also failed to reduce the proportion of polyinnervated end plates in the reinnervated facial muscles. Accordingly, continuous ultrasound therapy failed to restore any parameter of the motor performance of the vibrissal hairs. Application of pulsed ultrasound therapy promoted slight improvements of the functional parameters angular velocity and acceleration. The inhomogeneous structural and functional results achieved after both types of ultrasound therapy let us conclude that further studies are required to evaluate its effects on peripheral nerve regeneration. Anat Rec, 302:1314-1324, 2019. © 2019 Wiley Periodicals, Inc.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ar.24122
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http://dx.doi.org/10.1002/ar.24122DOI Listing
August 2019
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1 Citation
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References

(Supplied by CrossRef)

Beurskens C et al.
2005
Disorganization of the facial nucleus after nerve lesioning and regeneration in the rat: Effects of transplanting candidate reparative cells to the site of injury
Choi D et al.
Neurosurgery 2005

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