Expression and significance of Th17 cells and related factors in patients with autoimmune hepatitis.

Authors:
Jihong An
Jihong An
The Inner Mongolia People's Hospital

Comb Chem High Throughput Screen 2019 Apr 2. Epub 2019 Apr 2.

Department of Infectious Diseases, Inner Mongolia People's Hospital, Inner Mongolia 010017. China.

Aim And Objective: This study aims to investigate the expression and clinical significance of Th17 cells and related factors in peripheral blood of patients with autoimmune hepatitis (AIH).

Materials And Methods: A retrospective selection of 100 patients with AIH were included as study group, and 100 healthy volunteers in the outpatient clinic were selected as the control group. The levels of IL-17, IL-6, IL-21 and TNF-α in peripheral blood of all subjects were detected by enzyme-linked immunosorbent assay and the frequency of Th17 cells and Treg cells was detected by flow cytometry.

Results: Results showed that the study group had higher levels of serum total bilirubin (TBil), alkaline phosphatase (ALP), γ-glutamyltranspeptidase (γ-GT), immunoglobulin G (IgG), immunoglobulin M (IgM), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) than control group, as well as higher levels of IL-17, IL-6, IL-21 and TNF-α in serum. The frequency of Th17 cells in peripheral blood was higher in study group while the frequency of Treg cells was lower. Also, serum IL-17, TNF-α levels and Th17 cells frequency were positively correlated with ALT and AST, whereas Treg cells frequency were negatively correlated with ALT and AST levels.

Conclusion: Our finding demonstrates that Th17 cell frequency and their related factors IL-17 and TNF-α, are associated with liver damage, which might be used to monitor AIH disease severity.

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Source
http://dx.doi.org/10.2174/1386207322666190402160455DOI Listing
April 2019
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