Location is the key to function: HMGB1 in sepsis and trauma-induced inflammation.

Authors:
Meihong Deng
Meihong Deng
University Hospital Essen
Germany
Melanie J Scott
Melanie J Scott
University of Pittsburgh School of Medicine
United States
Jie Fan
Jie Fan
University of Pittsburgh School of Medicine
Pittsburgh | United States
Timothy R Billiar
Timothy R Billiar
University of Pittsburgh
United States

J Leukoc Biol 2019 Apr 4. Epub 2019 Apr 4.

Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

High mobility group box 1 (HMGB1) is a multifunctional nuclear protein, probably known best as a prototypical alarmin or damage-associated molecular pattern (DAMP) molecule when released from cells. However, HMGB1 has multiple functions that depend on its location in the nucleus, in the cytosol, or extracellularly after either active release from cells, or passive release upon lytic cell death. Movement of HMGB1 between cellular compartments is a dynamic process induced by a variety of cell stresses and disease processes, including sepsis, trauma, and hemorrhagic shock. Location of HMGB1 is intricately linked with its function and is regulated by a series of posttranslational modifications. HMGB1 function is also regulated by the redox status of critical cysteine residues within the protein, and is cell-type dependent. This review highlights some of the mechanisms that contribute to location and functions of HMGB1, and focuses on some recent insights on important intracellular effects of HMGB1 during sepsis and trauma.

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http://dx.doi.org/10.1002/JLB.3MIR1218-497RDOI Listing
April 2019
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References

(Supplied by CrossRef)
The mouse gene coding for high mobility group 1 protein (HMG1)
Ferrari S et al.
J Biol Chem 1994

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