Vitamin D3 supplementation and treatment outcomes in patients with depression (D3-vit-dep).

Authors:
Jens Peter Hansen
Jens Peter Hansen
Psychiatric Unit
Manan Pareek
Manan Pareek
Aarhus Universitetshospital
Denmark
Allan Hvolby
Allan Hvolby
Department of Child and Adolescent Psychiatry
Anne Schmedes
Anne Schmedes
Vejle County Hospital
Give | Denmark
Tomas Toft
Tomas Toft
Research Clinic for Functional Disorders and Psychosomatics
Erik Dahl
Erik Dahl
Johns Hopkins School of Medicine
United States

BMC Res Notes 2019 Apr 3;12(1):203. Epub 2019 Apr 3.

Mental Health Services in Esbjerg, Region of Southern Denmark, Gl. Vardevej 101, DK-6715, Esbjerg N, Denmark.

Objective: To examine whether vitamin D supplementation in patients with depression would result in a reduction in Hamilton D-17 depression score (primary outcome) at 3 and 6 months compared to controls and to explore the correlations between serum vitamin D and symptoms of depression, wellbeing, systolic blood pressure, and waist circumference. In this outpatient multicentre study conducted between 2010 and 2013, patients, 18-65 years old, diagnosed with mild to severe depression were randomly assigned to receive D supplementation 70 micrograms daily or placebo on top of standard treatment. Participants, care givers and those assessing the outcomes were blinded to group assignment.

Results: At baseline, 23 patients had a normal 25(OH)D level, 22 had insufficiency (< 25 nmol/L), and 17 had deficiency (25-50 nmol/L). No significant reduction in depression was seen after vitamin D supplementation compared to placebo at Hamilton (18.4-18.0; p = 0.73 at 12 weeks). Vitamin D supplementation did not provide a reduction in symptom score among patients with depression. Trial registration The trial was registered in the National Board of Health (EudraCT: 2011-002585-20) and in ClinicalTrials.Gov (NCT01390662).

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Source
http://dx.doi.org/10.1186/s13104-019-4218-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446320PMC
April 2019

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