Epidemiology and clinical features of viral anterior uveitis in southern Taiwan-diagnosis with polymerase chain reaction.

Authors:
Ming-Tse Kuo
Ming-Tse Kuo
Chang Gung Memorial Hospital
Taiwan
Tsai-Ling Chao
Tsai-Ling Chao
Kaohsiung Chang Gung Memorial Hospital
Taiwan
Hsi-Kung Kuo
Hsi-Kung Kuo
Chang Gung Memorial Hospital
Taiwan

BMC Ophthalmol 2019 Apr 3;19(1):87. Epub 2019 Apr 3.

Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123, Dapi Rd., Niaosong Dist, Kaohsiung, 833, Taiwan.

Background: To report the epidemiology and clinical features of viral anterior uveitis in patients in southern Taiwan.

Methods: A retrospective, case series study. HLA-B27 negative anterior uveitis patients with increased intraocular pressure or corneal edema seen at Kaohsiung Chang Gung Memorial Hospital from January 1, 2007 to January 31, 2018 had their aqueous sent for polymerase chain reaction analysis. Their records were reviewed for demographic data, ocular findings, and laboratory results.

Results: In the aqueous samples obtained from 102 eligible eyes, 42 eyes were herpesviridae-positive, which included 9 with herpes simplex virus (8.8%), 5 with varicella-zoster virus (4.9%), 27 with cytomegalovirus (26.5%), and 1 with Epstein-Barr virus (1%). Herpesviridae-positive patients were more likely to be male, and have glaucoma. Glaucoma and pseudophakic eyes were significantly associated with CMV-positive eyes.

Conclusion: PCR analysis of the anterior chamber fluid is important for the confirmation of the diagnosis of viral anterior uveitis. Cytomegalovirus anterior uveitis is not uncommon in patients in southern Taiwan, and it may follow an uneventful cataract extraction in immunocompetent patients.

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12886-019-1093-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448235PMC
April 2019
4 Reads

Publication Analysis

Top Keywords

anterior uveitis
20
viral anterior
12
polymerase chain
8
chain reaction
8
uveitis patients
8
patients southern
8
clinical features
8
features viral
8
epidemiology clinical
8
anterior
6
uveitis
5
patients
5
2018 aqueous
4
pseudophakic eyes
4
aqueous polymerase
4
reaction analysis
4
simplex virus
4
analysis records
4
chamber fluid
4
january 2018
4

References

(Supplied by CrossRef)
Article in Ocul Immunol Inflamm
T Tsirouki et al.
Ocul Immunol Inflamm 2018
Article in Eur J Ophthalmol
E Miserocchi et al.
Eur J Ophthalmol 2013
Article in Indian J Ophthalmol
NA Rao et al.
Indian J Ophthalmol 2013
Article in Medicine
B Bodaghi et al.
Medicine 2001
Article in Prog Retin Eye Res
MD Smet de et al.
Prog Retin Eye Res 2011
Article in Ocul Immunol Inflamm
JH Chang et al.
Ocul Immunol Inflamm 2002
Article in Surv Ophthalmol
JH Chang et al.
Surv Ophthalmol 2005
Article in Semin Ophthalmol
EM D'Ambrosio et al.
Semin Ophthalmol 2017
Article in Graefes Arch Clin Exp Ophthalmol
M Accorinti et al.
Graefes Arch Clin Exp Ophthalmol 2014
Article in Am J Ophthalmol
SP Chee et al.
Am J Ophthalmol 2008
Article in Ophthalmology
SP Chee et al.
Ophthalmology 2007

Similar Publications