Chemical Compositions of Metals in Bhasmas and Tibetan Zuotai Are a Major Determinant of Their Therapeutic Effects and Toxicity.

Authors:
Jie Liu
Jie Liu
University of Virginia
Charlottesville | United States
Feng Zhang
Feng Zhang
College of Pharmacy
China
Olumayokun A Olajide
Olumayokun A Olajide
School of Applied Sciences
Cen Li
Cen Li
Sun Yat-sen University
China
Li-Xin Wei
Li-Xin Wei
Eastern Hepatobiliary Surgery Hospital
China

Evid Based Complement Alternat Med 2019 10;2019:1697804. Epub 2019 Jan 10.

Qinghai Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China.

Minerals are alchemically processed as Bhasmas in Ayurvedic medicines or as Zuotai in Tibetan medicines. Ayurveda is a knowledge system of longevity and considers the mineral elixir made from "nature" capable of giving humans perpetual life. Herbo-metallic preparations have a long history in the treatment of various diseases in India, China, and around the world. Their disposition, pharmacology, efficacy, and safety require scientific evaluation. This review discusses the Bhasmas in Ayurvedic medicines and Zuotai in Tibetan medicines for their occurrence, bioaccessibility, therapeutic use, pharmacology, toxicity, and research perspectives. A literature search on Mineral, Bhasma, Ayurvedic medicine, Zuotai, Tibetan medicine, and Metals/metalloids from PubMed, Google and other sources was carried out, and the relevant papers on their traditional use, pharmacology, and toxicity were selected and analyzed. Minerals are processed to form Bhasma or Zuotai to alter their physiochemical properties distinguishing them from environmental metals. The metals found in Ayurveda are mainly from the intentional addition in the form of Bhasma or Zuotai. Bhasma and Zuotai are often used in combination with other herbals and/or animal-based products as mixtures. The advanced technologies are now utilized to characterize herbo-metallic preparations as Quality Assurance/Quality Control. The bioaccessibility, absorption, distribution, metabolism, and elimination of herbo-metallic preparations are different from environmental metals. The pharmacological basis of Bhasma in Ayurveda and Zuotai in Tibetan medicines and their interactions with drugs require scientific research. Although the toxic potentials of Bhasma and Zuotai differ from environmental metals, the metal poisoning case reports, especially lead (Pb), mercury (Hg), and arsenic (As) from inappropriate use of traditional medicines, are increasing, and pharmacovigilance is desired. In risk assessment, chemical forms of metals in Bhasma and Zuotai should be considered for their disposition, efficacy, and toxicity.

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/1697804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421027PMC
January 2019
4 Reads

Publication Analysis

Top Keywords

bhasma zuotai
20
zuotai tibetan
16
herbo-metallic preparations
12
tibetan medicines
12
environmental metals
12
zuotai
10
form bhasma
8
require scientific
8
medicines zuotai
8
ayurvedic medicines
8
bhasmas ayurvedic
8
pharmacology toxicity
8
bhasma
7
metals
6
medicines
6
tibetan
5
metals ayurveda
4
ayurveda intentional
4
metals metals
4
physiochemical properties
4

References

(Supplied by CrossRef)
Article in Journal of Trace Elements in Medicine and Biology
Journal of Trace Elements in Medicine and Biology 2018

2015

Similar Publications