Effect of food intake on 92 oncological biomarkers by the Proseek Oncology II panel.

Authors:
Joanna Hlebowicz
Joanna Hlebowicz
Malmö University Hospital

BMC Res Notes 2019 Apr 2;12(1):199. Epub 2019 Apr 2.

Department of Clinical Sciences, Division of Medicine, Skåne University Hospital, Lund University, Malmö, Sweden.

Objective: To evaluates the effect of food intake on 92 oncological biomarkers to evaluate whether the timing of blood sampling could be relevant. Twenty-two healthy subjects were investigated. A total of 92 biomarkers were measured before a standardised meal as well as 30 and 120 min afterwards with the Proseek Multiplex Oncology II kit.

Results: The levels of 6 biomarkers decreased significantly (P < 0.001) 30 min after food intake, and 4 biomarkers remained decreased (P < 0.001) 120 min after food intake. One biomarker was significantly increased (P < 0.001) at both 30 and 120 min after food intake. Some changes were less than 10%. Those biomarkers that showed a difference of more than 10% include: Granzyme H (13%), Methionine aminopeptidase 2 (14%), Secretory carrier-associated membrane protein 3 (39%), FAS-associated death domain protein (41%), and Pancreatic prohormone (79%). This study shows that food intake has a very modest effect on 92 different oncological biomarkers. Trial registration National Library of Medicine trial registration number NCT01027507 (retrospectively registered on December 8, 2009).

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Source
http://dx.doi.org/10.1186/s13104-019-4237-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446403PMC
April 2019
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