Clinical presentation and hematological profile among young and old chronic lymphocytic leukemia patients in Sudan.

BMC Res Notes 2019 Apr 2;12(1):202. Epub 2019 Apr 2.

Department of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan.

Objective: To assess the clinical presentation and hematological profile among young (≤ 55 years) and old (> 55 years) chronic lymphocytic leukemia patients in Sudan.

Result: In the present cross-sectional descriptive study, out of 110 cases studied, among them 31 (28.2%) were young (≤ 55 years) patients with mean age 48 years, and 79 (71.8%) were elder patients (> 55 years) with mean age 66 years, the overall mean age was 62.97 ± 12.06 with range (22-85 years), and 79 (71.8%) were males and 31 (28.2%) were females (M:F = 2.6:1) (P = 0.000). (7.3%) were asymptomatic, 61 (55.5%) presented with nonspecific complains. Generalized lymphadenopathy was seen in 52 (47.27%) with elder predominance (P = 0.03). Splenomegaly, hepatomegaly, thrombocytopenia and anemia were seen in 54 (49.1%), 14 (12.7%), 43 (39.1%) and 38 (34.5%) of patients respectively with male predominance. 54 (49.1%) and 42 (38.18%) of patients presented at Rai high risk and Binet C stages respectively with nearly same age and sex distribution. CLL in Sudan is a disease of elders, same as seen in literature, with high male to female ratio. In general hematological parameters means were noted to be distributed equally according to age and sex groups. Majority of patients were presented with nonspecific symptoms and nearly half of patients presented at late stages as reported in most developing countries.

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13104-019-4239-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446286PMC
April 2019
68 Reads

Article Mentions


Provided by Crossref Event Data
datacite
Datacite: Datacite
April 3, 2019, 12:34 am EST

Publication Analysis

Top Keywords

patients presented
12
lymphocytic leukemia
8
patients
8
leukemia patients
8
young ≤ 55 years
8
presented nonspecific
8
profile young
8
chronic lymphocytic
8
age sex
8
clinical presentation
8
hematological profile
8
presentation hematological
8
age
5
presented
4
asymptomatic 555%
4
complains generalized
4
555% presented
4
hematological parameters
4
stages age
4
binet stages
4

References

(Supplied by CrossRef)
Article in Blood
M Hallek et al.
Blood 2008
Article in N Engl J Med
O Landgren et al.
N Engl J Med 2009
Article in Blood
S O’Brien et al.
Blood 1995

M Linet et al.
1988
Article in Leukemia
L Chan et al.
Leukemia 1997

D Crowther-Swanepoel et al.
2010
Article in Leukemia Lymphoma
J-Y Yoon et al.
Leukemia Lymphoma 2012
Article in Blood
FR Mauro et al.
Blood 1999
Article in Leuk Res
M Seftel et al.
Leuk Res 2009
Article in Ann Intern Med
TD Shanafelt et al.
Ann Intern Med 2006
Article in UpToDate.
KR Rai et al.
UpToDate. 2006

Similar Publications