Prevalence of glucose-6-phosphate dehydrogenase deficiency in Cameroonian blood donors.

Authors:
Stephanie M Lauden
Stephanie M Lauden
Case Western Reserve University
United States
Ethan Helm
Ethan Helm
Mbingo Baptist Hospital
Sarah E Cusick
Sarah E Cusick
The Johns Hopkins Bloomberg School of Public Health
United States
Tina M Slusher
Tina M Slusher
University of Minnesota
United States
Troy C Lund
Troy C Lund
University of Minnesota
United States

BMC Res Notes 2019 Apr 2;12(1):195. Epub 2019 Apr 2.

Division of Global Pediatrics, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.

Objective: Deficiency in G6PD is the most common enzymopathy worldwide. It is frequently found in individuals of African descent in whom it can lead to hemolytic crises triggered by the use of certain antimalarial medications and infection. The prevalence of G6PD deficiency and its contribution to morbidity in West Africa is under-studied. To understand the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in West African blood donors.

Results: We evaluated the G6PD status and infectious disease screening tests of 1001 adult male Cameroonian blood donors (mean age 31.7 ± 9.8 years). The prevalence of G6PD deficiency was 7.9%. There was no difference in levels of hemoglobin or ABO subtype between those who were G6PD-normal compared to those that were deficient. Interestingly, G6PD-normal vs. deficient blood donors were less likely to have screened positive for hepatitis C virus (p = 0.02) and rapid plasma reagin (indicative of syphilis, p = 0.03). There was no significant difference in hepatitis B sAg, HIV-1, or HIV-2 reactivity between those with vs. without G6PD sufficiency. These data suggest that G6PD deficiency is common among West African male blood donors and may be associated with specific infectious disease exposure.

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Source
http://dx.doi.org/10.1186/s13104-019-4226-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444568PMC
April 2019
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