Multi-organ involvement secondary to varicella zoster virus, herpes simplex virus and cytomegalovirus in an immunocompromised patient.

Authors:
Ripal Jariwala
Ripal Jariwala
Tampa General Hospital
Tampa | United States
Kristen Zeitler
Kristen Zeitler
Tampa General Hospital
Tampa | United States
Nicole D Riddle
Nicole D Riddle
University of South Florida College of Medicine
United States
Chakrapol Sriaroon
Chakrapol Sriaroon
Queen Saovabha Memorial Institute
Thailand

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Division of Pulmonaryand Critical Care Medicine, University of South Florida, Tampa, Florida, USA.

The use of immunosuppressing agents can act as a catalyst for viral reactivation, promoting systemic infection with organ involvement. Current literature remains sparse on this topic but does provide individual case reports involving single viruses. We present the case of an immunocompromised patient with skin lesions, pancreatitis, colitis and hepatitis. Work-up revealed varicella zoster virus, which likely put the patient at risk for multi-organ involvement, as well as clinical suspicion of other implicated viruses, specifically herpes simplex virus and cytomegalovirus. A high clinical index of suspicion along with biopsy guidance for viral involvement in immunocompromised patients is crucial for early diagnosis and treatment of these conditions.

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Source
http://dx.doi.org/10.1136/bcr-2018-228150DOI Listing
March 2019
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References

(Supplied by CrossRef)
Herpes simplex pancreatitis
Shintaku et al.
Arch Pathol Lab Med 2003
Varicella-associated colitis in a 6-month-old infant
Eren et al.
J Pediatr Gastroenterol Nutr 2006

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