Clinical and Epidemiological Patterns of Scrub Typhus, an Emerging Disease in Bhutan.

Authors:
Sithar Dorjee
Sithar Dorjee
Atlantic Veterinary College
Peter Jolly
Peter Jolly
Institute of Veterinary
Trinidad and Tobago
Roger Morris
Roger Morris
King's College London
United Kingdom
Nelly Marquetoux
Nelly Marquetoux
Institute of Veterinary
Tabriz | Iran

Trop Med Infect Dis 2019 Mar 29;4(2). Epub 2019 Mar 29.

School of Veterinary Science, Massey University, Palmerston North 4442, New Zealand.

Scrub typhus (ST) is a vector-borne rickettsial infection causing acute febrile illness. The re-emergence of ST in the Asia-Pacific region represents a serious public health threat. ST was first detected in Bhutan in 2008. However, the disease is likely to be under-diagnosed and under-reported, and the true impact is difficult to estimate. At the end of 2014, the SD Bioline Tsutsugamushi Test rapid diagnostic test (RDT) kits became available in all hospitals to assist clinicians in diagnosing ST. We conducted a retrospective descriptive study, reviewing records from all hospitals of Bhutan to identify all RDT-positive clinical cases of ST in Bhutan in 2015. The aim was to evaluate the burden of ST in Bhutan, describe the demographic, spatial and temporal patterns of disease, and identify the typical clinical presentations. The annual incidence of RDT-positive cases of ST reporting to Bhutanese hospitals in 2015 was estimated to be 62 per 100,000 population at risk. The incidence of disease was highest in the southern districts with a subtropical climate and a high level of agricultural production. The highest proportion of cases (87%) was rural residents, with farmers being the main occupational category. The disease was strongly seasonal, with 97% of cases occurring between June and November, coinciding with the monsoon and agricultural production seasons. Common ST symptoms were not specific, and an eschar was noted by clinicians in only 7.4% of cases, which is likely to contribute to an under-diagnosis of ST. ST represents an important and neglected burden, especially in rural communities in Bhutan. The outcomes of this study will inform public health measures such as timely-awareness programmes for clinicians and the public in high-risk areas, to improve the diagnosis, treatment and clinical outcomes of this disease.

Download full-text PDF

Source
http://dx.doi.org/10.3390/tropicalmed4020056DOI Listing
March 2019
4 Reads

Publication Analysis

Top Keywords

public health
8
scrub typhus
8
agricultural production
8
bhutan
6
disease
6
cases
5
incidence disease
4
disease highest
4
highest southern
4
bhutanese hospitals
4
risk incidence
4
population risk
4
2015 estimated
4
estimated 100000
4
100000 population
4
hospitals 2015
4
southern districts
4
climate high
4
highest proportion
4
proportion cases
4

References

(Supplied by CrossRef)
63—Scrub Typhus
Newton et al.
2013
Scrub Typhus: An Emerging Threat
Chakraborty et al.
Indian J. Dermatol. 2017

Similar Publications