The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study.

Authors:
Tim Rattay
Tim Rattay
University Hospitals Coventry and Warwickshire
United Kingdom
Rajiv V Dave
Rajiv V Dave
Leeds Teaching Hospital NHS Trust
Adam Trickey
Adam Trickey
School of Social and Community Medicine
Joanna Skillman
Joanna Skillman
University Hospital Coventry and Warwickshire NHS Trust
United Kingdom
Matthew Gardiner
Matthew Gardiner
Royal Free Hospital
United Kingdom
Adrian Harnett
Adrian Harnett
Norfolk & Norwich University Hospital

Br J Cancer 2019 Apr 29;120(9):883-895. Epub 2019 Mar 29.

Linda McCartney Centre, Royal Liverpool and Broadgreen University Hospital, Prescot Street, Liverpool, L7 8XP, UK.

Background: Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy.

Methods: Consecutive women undergoing mastectomy ± IBR for breast cancer July-December, 2016 were included. Patient demographics, operative, oncological and complication data were collected. Time from last definitive cancer surgery to first adjuvant treatment for patients undergoing mastectomy ± IBR were compared and risk factors associated with delays explored.

Results: A total of 2540 patients were recruited from 76 centres; 1008 (39.7%) underwent IBR (implant-only [n = 675, 26.6%]; pedicled flaps [n = 105,4.1%] and free-flaps [n = 228, 8.9%]). Complications requiring re-admission or re-operation were significantly more common in patients undergoing IBR than those receiving mastectomy. Adjuvant chemotherapy or radiotherapy was required by 1235 (48.6%) patients. No clinically significant differences were seen in time to adjuvant therapy between patient groups but major complications irrespective of surgery received were significantly associated with treatment delays.

Conclusions: IBR does not result in clinically significant delays to adjuvant therapy, but post-operative complications are associated with treatment delays. Strategies to minimise complications, including careful patient selection, are required to improve outcomes for patients.

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Source
http://www.nature.com/articles/s41416-019-0438-1
Publisher Site
http://dx.doi.org/10.1038/s41416-019-0438-1DOI Listing
April 2019
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