The oxytocin receptor gene predicts brain activity during an emotion recognition task in autism.

Mol Autism 2019 12;10:12. Epub 2019 Mar 12.

2Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.

Background: Autism is a highly varied and heritable neurodevelopmental condition, and common variants explain approximately 50% of the genetic variance of autism. One of the genes implicated in autism is the oxytocin receptor (). The current study combined genetic and brain imaging (fMRI) data to examine the moderating effect of genotype on the association between diagnosis and brain activity in response to a test of cognitive empathy.

Methods: Participants were adolescents (mean age = 14.7 ± 1.7) who were genotyped for single nucleotide polymorphisms (SNPs) within the and underwent functional brain imaging while completing the adolescent version of the 'Reading the Mind in the Eyes' Test (Eyes Test).

Results: Two (rs2254298, rs53576) of the five SNPs examined were significantly associated with brain activity during the Eyes Test, and three of the SNPs (rs2254298, rs53576, rs2268491) interacted with diagnostic status to predict brain activity. All of the effects localized to the right supramarginal gyrus (rSMG) and an overlap analysis revealed a large overlap of the effects. An exploratory analysis showed that activity within an anatomically defined rSMG and genotype can predict diagnostic status with reasonable accuracy.

Conclusions: This is one of the first studies to investigate and brain function in autism. The findings suggest a neurogenetic mechanism by which -dependent activity within the rSMG is related to the aetiology of autism.

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13229-019-0258-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419364PMC
May 2019
2 Reads

Publication Analysis

Top Keywords

brain activity
16
brain imaging
8
rs2254298 rs53576
8
diagnostic status
8
oxytocin receptor
8
brain
7
autism
6
activity
6
age = 147 ± 17 genotyped
4
overlap effects
4
single nucleotide
4
genotyped single
4
effects exploratory
4
imaging completing
4
polymorphisms snps
4
snps underwent
4
underwent functional
4
revealed large
4
exploratory analysis
4
functional brain
4

Altmetric Statistics

References

(Supplied by CrossRef)

AP Jones et al.
J Child Psychol Psychiatry 2010

EJ Lawrence et al.
Psychol Med 2004

S Baron-Cohen et al.
J Child Psychol Psychiatry 2001

P Rueda et al.
Eur J Dev Psychol 2015

S Baron-Cohen et al.
J Autism Dev Disord. 2004

DH Geschwind et al.
Curr Opin Neurobiol. 2007

BR Bill et al.
Curr Opin Genet Dev. 2009

T Gaugler et al.
Nat Genet. 2014

L Byrge et al.
J Neurosci. 2015

Similar Publications