Multiple Myeloma patients who are infected with Epstein Virus do better

Sheerien Rajput, Khurram Minhas, Iqbal Azam, Usman Shaikh, Azhar Hussain, El-Nasir Lalani

Overview

The presence of a Epstein Barr Virus in the bone marrow of the majority of patients seen was surprising. What was more surprising is that the virus was in areas close to the tumour cells and these patients do better.

Summary

It is important to check the bone marrow biopsies of patients for expression of Epstein Barr Virus as this May influence prognosis

Altmetric Statistics

LMP1 expression in bone marrow trephines of patients with multiple myeloma confers a survival advantage.

Authors:
El-Nasir Lalani
El-Nasir Lalani
AGA Khan Univerity
Founding Director and Professor
Pathology, Oncology,
Karachi, Sindh | Pakistan

Leuk Lymphoma 2019 08 26;60(8):1991-2001. Epub 2019 Mar 26.

a Centre for Regenerative Medicine and Stem Cell Research, Aga Khan University , Karachi , Pakistan.

Multiple myeloma (MM) is a heterogeneous disease of the bone marrow (BM). Its association with Epstein-Barr virus (EBV) remains enigmatic. Aim of our study was to determine expression of latent membrane protein 1 (LMP1), aldehyde dehydrogenase 1 (ALDH1), CD117 and their association with 5-year survival in MM patients. Seven percent of cases expressed LMP1 in MM cells with no association with survival. Whereas, LMP1 expression in CD138- non-neoplastic cells was observed in 80% of the cases, conferring a survival advantage of 1.75 years (mean 3.75 ± 0.28, 95% CI 3.19-4.3). LMP1 in CD138- non-neoplastic cells was associated with CD117 expression in MM cells. Combinatorial analysis of LMP1 and CD117 stratified patients into good prognostic group LMP1+/CD117- (mean survival 4.16 ± 0.39 years) and a worst prognostic group; LMP1-/CD117+ (mean survival 1.02 ± 0.29 years). Our study showed that LMP1 expression in CD138- non-neoplastic cells of BM in MM patients confers a survival advantage.

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Source
https://www.tandfonline.com/doi/full/10.1080/10428194.2018.1
Publisher Site
http://dx.doi.org/10.1080/10428194.2018.1563697DOI Listing
August 2019
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References

(Supplied by CrossRef)

Neparidze N et al.
Clin Adv Hematol Oncol 2014

Chen YP et al.
Oncotarget 2015

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