Distribution of Distances Between Symmetric Words in the Human Genome: Analysis of Regular Peaks.

Interdiscip Sci 2019 Sep 25;11(3):367-372. Epub 2019 Mar 25.

Department of Medical Sciences, iBiMED, IEETA-Institute of Electronics and Informatics Engineering of Aveiro, University of Aveiro, Campus Universitário de Santiago, Aveiro, Portugal.

Finding DNA sites with high potential for the formation of hairpin/cruciform structures is an important task. Previous works studied the distances between adjacent reversed complement words (symmetric word pairs) and also for non-adjacent words. It was observed that for some words a few distances were favoured (peaks) and that in some distributions there was strong peak regularity. The present work extends previous studies, by improving the detection and characterization of peak regularities in the symmetric word pairs distance distributions of the human genome. This work also analyzes the location of the sequences that originate the observed strong peak periodicity in the distance distribution. The results obtained in this work may indicate genomic sites with potential for the formation of hairpin/cruciform structures.

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http://dx.doi.org/10.1007/s12539-019-00326-xDOI Listing
September 2019

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