Int J Med Sci 2019 29;16(3):416-423. Epub 2019 Jan 29.
Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Ishikawa 920-0293, Japan.
: We recently reported that WNT10A plays a pivotal role in wound healing by regulating collagen expression/synthesis, as the depletion of WNT10A dramatically delays skin ulcer formation. WNT signaling also has a close correlation with the cancer microenvironment and proliferation, since tumors are actually considered to be 'unhealing' or 'overhealing' wounds. To ascertain the regulatory functions of WNT10A in tumor growth, we examined the net effects of WNT10A depletion using -deficient mice (). : We subjected C57BL/6J wild-type (WT) or mice to murine melanoma B16-F10 cell transplantation. mice showed a significantly smaller volume of transplanted melanoma as well as fewer microvessels and less collagen expression and more necrosis than WT mice. : Taken together, our observations suggest that critical roles of -depleted anti-stromagenesis prevent tumor growth, in contrast with true wound healing/scarring.