Depletion of WNT10A Prevents Tumor Growth by Suppressing Microvessels and Collagen Expression.

Int J Med Sci 2019 29;16(3):416-423. Epub 2019 Jan 29.

Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Ishikawa 920-0293, Japan.

: We recently reported that WNT10A plays a pivotal role in wound healing by regulating collagen expression/synthesis, as the depletion of WNT10A dramatically delays skin ulcer formation. WNT signaling also has a close correlation with the cancer microenvironment and proliferation, since tumors are actually considered to be 'unhealing' or 'overhealing' wounds. To ascertain the regulatory functions of WNT10A in tumor growth, we examined the net effects of WNT10A depletion using -deficient mice (). : We subjected C57BL/6J wild-type (WT) or mice to murine melanoma B16-F10 cell transplantation. mice showed a significantly smaller volume of transplanted melanoma as well as fewer microvessels and less collagen expression and more necrosis than WT mice. : Taken together, our observations suggest that critical roles of -depleted anti-stromagenesis prevent tumor growth, in contrast with true wound healing/scarring.

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.26997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428976PMC
July 2019
1 Read
2.003 Impact Factor

Publication Analysis

Top Keywords

tumor growth
12
depletion wnt10a
8
microvessels collagen
8
collagen expression
8
depletion -deficient
4
wnt10a depletion
4
effects wnt10a
4
mice
4
net effects
4
-deficient mice
4
wild-type mice
4
mice murine
4
c57bl/6j wild-type
4
subjected c57bl/6j
4
mice subjected
4
examined net
4
wnt10a tumor
4
tumors considered
4
considered 'unhealing'
4
proliferation tumors
4

Similar Publications