How rapid advances in imaging are defining the future of precision radiation oncology.

Authors:
Laura Beaton
Laura Beaton
John Curtin School of Medical Research
Australia
Steve Bandula
Steve Bandula
University College London
Mark N Gaze
Mark N Gaze
University College London Hospitals NHS Foundation Trust
United Kingdom
Ricky A Sharma
Ricky A Sharma
University of Oxford
United Kingdom

Br J Cancer 2019 Apr 26;120(8):779-790. Epub 2019 Mar 26.

Cancer Institute, University College London, London, UK.

Imaging has an essential role in the planning and delivery of radiotherapy. Recent advances in imaging have led to the development of advanced radiotherapy techniques-including image-guided radiotherapy, intensity-modulated radiotherapy, stereotactic body radiotherapy and proton beam therapy. The optimal use of imaging might enable higher doses of radiation to be delivered to the tumour, while sparing normal surrounding tissues. In this article, we review how the integration of existing and novel forms of computed tomography, magnetic resonance imaging and positron emission tomography have transformed tumour delineation in the radiotherapy planning process, and how these advances have the potential to allow a more individualised approach to the cancer therapy. Recent data suggest that imaging biomarkers that assess underlying tumour heterogeneity can identify areas within a tumour that are at higher risk of radio-resistance, and therefore potentially allow for biologically focussed dose escalation. The rapidly evolving concept of adaptive radiotherapy, including artificial intelligence, requires imaging during treatment to be used to modify radiotherapy on a daily basis. These advances have the potential to improve clinical outcomes and reduce radiation-related long-term toxicities. We outline how recent technological advances in both imaging and radiotherapy delivery can be combined to shape the future of precision radiation oncology.

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Source
http://dx.doi.org/10.1038/s41416-019-0412-yDOI Listing
April 2019

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