Antibody response to Phlebotomus perniciosus saliva in cats naturally exposed to phlebotomine sand flies is positively associated with Leishmania infection.

Authors:
Andre Pereira
Andre Pereira
Escola Nacional de Saúde Pública Sergio Arouca
Canada
Hugo Vilhena
Hugo Vilhena
Escola Universitária Vasco da Gama
Coimbra | Portugal
Angela Martins
Angela Martins
School of Dentistry
Joaquim Henriques
Joaquim Henriques
2Centro Veterinario Berna
Monica Coimbra
Monica Coimbra
4Clínica Veterinária Porto Seguro
Ana Catarino
Ana Catarino
Université Libre de Bruxelles
Belgium

Parasit Vectors 2019 Mar 26;12(1):128. Epub 2019 Mar 26.

Global Health and Tropical Medicine (GHMT), Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), Lisboa, Portugal.

Background: Zoonotic leishmaniosis, caused by the protozoan Leishmania infantum, is a public and animal health problem in Asia, Central and South America, the Middle East and the Mediterranean Basin. Several phlebotomine sand fly species from the subgenus Larroussius are vectors of L. infantum. Data from dogs living in endemic areas of leishmaniosis advocate the use of antibody response to phlebotomine sand fly saliva as an epidemiological biomarker for monitoring vector exposure. The aim of this study was to analyse the exposure of cats to phlebotomine sand flies using detection of IgG antibodies to Phlebotomus perniciosus saliva. The association between phlebotomine sand fly exposure and the presence of Leishmania infection was also investigated.

Results: IgG antibodies to P. perniciosus saliva were detected in 167 (47.7%) out of 350 cats; higher antibody levels were present in sera collected during the period of phlebotomine sand fly seasonal activity (OR = 19.44, 95% CI: 9.84-38.41). Cats of 12-35 months had higher antibody levels than younger ones (OR = 3.56, 95% CI: 1.39-9.16); this difference was also significant with older cats (for 36-95 months-old, OR = 9.43, 95% CI: 3.62-24.48; for older than 95 months, OR = 9.68, 95% CI: 3.92-23.91). Leishmania spp. DNA was detected in the blood of 24 (6.9%) cats, while antibodies to L. infantum were detected in three (0.9%). Only one cat was positive to Leishmania by both techniques. Cats presenting IgG antibodies to P. perniciosus had a significantly higher risk of being positive for Leishmania infection.

Conclusions: To our knowledge, this is the first study demonstrating anti-sand fly saliva antibodies in cats. The evaluation of the contact of this animal species with the vector is important to the development of prophylactic measures directed to cats, with the aim of reducing the prevalence of infection in an endemic area. Therefore, studies evaluating whether the use of imidacloprid/flumethrin collars reduces the frequency of P. perniciosus bites in cats are needed. It is also important to evaluate if there is a correlation between the number of phlebotomine sand fly bites and IgG antibody levels.

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13071-019-3376-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434892PMC

Still can't find the full text of the article?

We can help you send a request to the authors directly.
March 2019
2 Reads

Publication Analysis

Top Keywords

phlebotomine sand
28
sand fly
20
antibody levels
12
perniciosus saliva
12
igg antibodies
12
cats
10
sand flies
8
leishmania infection
8
antibodies perniciosus
8
positive leishmania
8
antibody response
8
higher antibody
8
phlebotomus perniciosus
8
phlebotomine
7
sand
7
leishmania
6
fly
6
perniciosus
5
antibody
5
period phlebotomine
4

References

(Supplied by CrossRef)
Article in Parasit Vectors.
M-G Pennisi et al.
Parasit Vectors. 2015
Article in Trends Parasitol.
C Maia et al.
Trends Parasitol. 2011

C Maia et al.
2018
Article in PLoS Negl Trop Dis.
T Lestinova et al.
PLoS Negl Trop Dis. 2017
Article in PLoS Negl Trop Dis.
C Teixeira et al.
PLoS Negl Trop Dis. 2010
Article in PLoS Negl Trop Dis.
M Vlkova et al.
PLoS Negl Trop Dis. 2011
Article in PLoS Negl Trop Dis.
T Kostalova et al.
PLoS Negl Trop Dis. 2015
Article in Med Vet Entomol.
T Kostalova et al.
Med Vet Entomol. 2017
Article in Sci Rep.
MS Solcà et al.
Sci Rep. 2016
Article in Parasit Vectors.
RJ Quinnell et al.
Parasit Vectors. 2018
Article in Parasit Vectors.
R Velez et al.
Parasit Vectors. 2018

Similar Publications