Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer's Disease.

Authors:
Raluca Stefanescu
Raluca Stefanescu
University of Konstanz
Germany
Gabriela Dumitrita Stanciu
Gabriela Dumitrita Stanciu
University of Agricultural Sciences and Veterinary Medicine "Ion Ionescu de la Brad"
Andrei Luca
Andrei Luca
Center for the Study and Therapy of Pain
Bogdan Ionel Tamba
Bogdan Ionel Tamba
Grigore T. Popa University of Medicine and Pharmacy Iasi Universitatii 15
Cosmin Teodor Mihai
Cosmin Teodor Mihai
"Alexandru Ioan Cuza" University of Iasi
Romania

Molecules 2019 Mar 24;24(6). Epub 2019 Mar 24.

Center for Advanced Research and Development in Experimental Medicine (CEMEX), "Grigore T. Popa" University of Medicine and Pharmacy, 16 Universității Street, 700115 Iaşi, Romania.

Alzheimer's Disease affects approximately 33 million people worldwide and is characterized by progressive loss of memory at the cognitive level. The formation of toxic amyloid oligomers, extracellular amyloid plaques and amyloid angiopathy in brain by amyloid beta peptides are considered a part of the identified mechanism involved in disease pathogenesis. The optimal treatment approach leads toward finding a chemical compound able to form a noncovalent complex with the amyloid peptide thus blocking the process of amyloid aggregation. This direction gained an increasing interest lately, many studies demonstrating that mass spectrometry is a valuable method useful for the identification and characterization of such molecules able to interact with amyloid peptides. In the present review we aim to identify in the scientific literature low molecular weight chemical compounds for which there is mass spectrometric evidence of noncovalent complex formation with amyloid peptides and also there are toxicity reduction results which verify the effects of these compounds on amyloid beta toxicity towards cell cultures and transgenic mouse models developing Alzheimer's Disease.

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Source
http://dx.doi.org/10.3390/molecules24061167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471768PMC
March 2019
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