[An investigation of vaccination in children with human immunodeficiency virus infection].

Authors:
Yi-yun Hu
Yi-yun Hu
Pediatric Research Institute
China
Ran Xiong
Ran Xiong
Shanghai Institutes for Biological Sciences
China
Hou-lin Tang
Hou-lin Tang
Sichuan University
China
Jun Zheng
Jun Zheng
Capital Medical University
China
Ping-Fang Zhang
Ping-Fang Zhang
Wuxi No.3 Hospital
China
Xi Chen
Xi Chen
State Key Laboratory of Pharmaceutical Biotechnology
China

Zhongguo Dang Dai Er Ke Za Zhi 2019 Mar;21(3):199-202

National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

Objective: To investigate the status of vaccination in children with human immunodeficiency virus (HIV) infection.

Methods: A questionnaire survey was performed in 148 children in Hunan province, China who were registered in China's Acquired Immune Deficiency Syndrome Comprehensive Response Information Management System up to December 31, 2016 and were aged <15 years at the time of confirmed diagnosis of HIV infection. The information on vaccination, diagnosis of HIV infection, and diagnosis and treatment of related diseases was collected.

Results: Of the 148 children with HIV infection, there were 70 boys (47.3%) and 78 girls (52.7%); 140 children had an age of 3.8 (0.2-14.8) years at the time of confirmed diagnosis, and 8 children refused to answer this question. Mother-to-child transmission was found in 133 children (91.7%), blood transmission in 1 child (0.7%), and unknown in 14 children (9.5%). Of the 148 children, 129 (87.2%) received antiviral therapy and 19 (12.8%) did not receive such treatment. The vaccination rates of hepatitis B vaccine, bacille Calmette-Guérin vaccine, poliomyelitis live attenuated vaccine and diphtheria-pertussis-tetanus vaccine ranged from 70.9% to 77.7%, which was significantly lower than the national level (≥97%); the vaccination rates of the other vaccines in the National Immunization Program gradually decreased with age. No severe adverse effects were reported after vaccination.

Conclusions: Mother-to-child transmission is the main route of HIV infection in Chinese children. The diagnosis of children with HIV infection is significantly delayed, with low vaccination rates. Efforts should be made to strengthen early diagnosis, early treatment and vaccination in children with HIV infection, in order to improve their quality of life.

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March 2019
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