Antierythropoietin Antibody Production Is Not Associated with Malaria and Malaria-Related Anaemia in Humans.

Authors:
eddie williams owiredu
eddie williams owiredu
Kwame Nkrumah University of Science and Technology
Kumasi, Ashanti | Ghana
Dr Otchere Addai-Mensah
Dr Otchere Addai-Mensah
Kwame Nkrumah University of Science and Technology
Senior Lecturer and Dean of Faculty
Immunology and Malariology
Kumasi, Ashanti | Ghana

ScientificWorldJournal 2019 14;2019:5398732. Epub 2019 Feb 14.

Department of Serology, Komfo Anokye Teaching Hospital, Kumasi, Ghana.

Introduction: The pathophysiology of malaria-related anaemia is not fully understood although increased destruction of parasitized and nonparasitized erythrocytes, as well as inadequate erythropoiesis, has been proposed. Circulating antierythropoietin (anti-EPO) antibodies have also been implicated in malaria and malaria-related anaemia in mice. However, studies on this association have not been investigated in humans. This study therefore determined the prevalence of anti-EPO antibody production and assessed its association with malaria and malaria-related anaemia in humans.

Methods: A total of 86 children aged 1-10 years (57 children with malaria serving as the case group and 29 healthy children serving as control), all residents of Duayaw Nkwanta, Ghana, were recruited for this case-control study. Venous blood was collected for thick and thin films for malaria microscopy, full blood count by automated haematology analyzer, and antierythropoietin antibody and erythropoietin estimation by sandwich ELISA method.

Results: Out of the 86 participants recruited, only 3 (3.5%) were positive for anti-EPO antibody; 2.3% of the case group; and 1.2% of the control group. There was no association between the cases and the controls in the production of anti-EPO antibodies. Erythropoietin concentration was significantly higher in malaria-related anaemic subjects (p=0.032).

Conclusion: Antierythropoietin antibodies are not associated with malaria infection and malaria-related anaemia in humans. Erythropoietin concentration is associated with malaria-related anaemia.

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Source
http://dx.doi.org/10.1155/2019/5398732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393884PMC
June 2019
11 Reads
1.219 Impact Factor

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