Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome.

Authors:
Basem M Alraddadi
Basem M Alraddadi
King Faisal Specialist Hospital and Research Center
Saudi Arabia
Ismael Qushmaq
Ismael Qushmaq
McMaster University
Canada
Yasser Mandourah
Yasser Mandourah
Riyadh Military Hospital
Saudi Arabia
Ghaleb A Almekhlafi
Ghaleb A Almekhlafi
Department of Intensive Care Services
Jesna Jose
Jesna Jose
Kent State University
United States
Ayman Kharaba
Ayman Kharaba
King Fahad Hospital
Riyadh | Saudi Arabia

Influenza Other Respir Viruses 2019 Mar 18. Epub 2019 Mar 18.

Intensive Care Department, King Abdullah International Medical Research Center, College of Medicine, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Background: Noninvasive ventilation (NIV) has been used in patients with the Middle East respiratory syndrome (MERS) with acute hypoxemic respiratory failure, but the effectiveness of this approach has not been studied.

Methods: Patients with MERS from 14 Saudi Arabian centers were included in this analysis. Patients who were initially managed with NIV were compared to patients who were managed only with invasive mechanical ventilation (invasive MV).

Results: Of 302 MERS critically ill patients, NIV was used initially in 105 (35%) patients, whereas 197 (65%) patients were only managed with invasive MV. Patients who were managed with NIV initially had lower baseline SOFA score and less extensive infiltrates on chest radiograph compared with patients managed with invasive MV. The vast majority (92.4%) of patients who were managed initially with NIV required intubation and invasive mechanical ventilation, and were more likely to require inhaled nitric oxide compared to those who were managed initially with invasive MV. ICU and hospital length of stay were similar between NIV patients and invasive MV patients. The use of NIV was not independently associated with 90-day mortality (propensity score-adjusted odds ratio 0.61, 95% CI [0.23, 1.60] P = 0.27).

Conclusions: In patients with MERS and acute hypoxemic respiratory failure, NIV failure was very high. The use of NIV was not associated with improved outcomes.

Download full-text PDF

Source
http://dx.doi.org/10.1111/irv.12635DOI Listing
March 2019
9 Reads
2.201 Impact Factor

Article Mentions


Provided by Crossref Event Data
twitter
Twitter:
April 5, 2019, 6:47 pm EST
twitter
Twitter:
April 5, 2019, 2:16 pm EST
twitter
Twitter:
April 5, 2019, 2:03 pm EST
twitter
Twitter:
April 5, 2019, 2:01 pm EST
twitter
Twitter:
March 30, 2019, 9:48 am EST
twitter
Twitter:
March 30, 2019, 8:00 am EST
twitter
Twitter:
March 21, 2019, 2:21 pm EST
twitter
Twitter:
March 20, 2019, 5:12 am EST
twitter
Twitter:
March 19, 2019, 3:14 pm EST
twitter
Twitter:
March 19, 2019, 2:29 pm EST
twitter
Twitter:
March 19, 2019, 1:42 pm EST
twitter
Twitter:
March 19, 2019, 1:30 pm EST
twitter
Twitter:
March 19, 2019, 1:18 pm EST
twitter
Twitter:
March 19, 2019, 11:23 am EST
twitter
Twitter:
March 19, 2019, 11:01 am EST
twitter
Twitter:
March 19, 2019, 10:55 am EST
twitter
Twitter:
March 19, 2019, 5:34 am EST
twitter
Twitter:
March 19, 2019, 4:13 am EST
twitter
Twitter:
March 19, 2019, 1:30 am EST
twitter
Twitter:
March 19, 2019, 1:29 am EST
twitter
Twitter:
March 19, 2019, 1:12 am EST
twitter
Twitter:
March 19, 2019, 1:05 am EST

Publication Analysis

Top Keywords

patients managed
20
patients
14
managed invasive
12
niv
9
hypoxemic respiratory
8
respiratory failure
8
acute hypoxemic
8
mers acute
8
niv patients
8
managed niv
8
managed initially
8
patients niv
8
invasive mechanical
8
niv initially
8
invasive patients
8
compared patients
8
mechanical ventilation
8
patients mers
8
patients middle
8
east respiratory
8

Altmetric Statistics

References

(Supplied by CrossRef)
Middle East respiratory syndrome
Arabi YM et al.
N Engl J Med 2017

Similar Publications