Ancestry-specific association mapping in admixed populations.

Genet Epidemiol 2019 07 18;43(5):506-521. Epub 2019 Mar 18.

Department of Biology, The Bioinformatics Centre, University of Copenhagen, Copenhagen, Denmark.

During the last decade genome-wide association studies have proven to be a powerful approach to identifying disease-causing variants. However, for admixed populations, most current methods for association testing are based on the assumption that the effect of a genetic variant is the same regardless of its ancestry. This is a reasonable assumption for a causal variant but may not hold for the genetic variants that are tested in genome-wide association studies, which are usually not causal. The effects of noncausal genetic variants depend on how strongly their presence correlate with the presence of the causal variant, which may vary between ancestral populations because of different linkage disequilibrium patterns and allele frequencies. Motivated by this, we here introduce a new statistical method for association testing in recently admixed populations, where the effect size is allowed to depend on the ancestry of a given allele. Our method does not rely on accurate inference of local ancestry, yet using simulations we show that in some scenarios it gives a substantial increase in statistical power to detect associations. In addition, the method allows for testing for difference in effect size between ancestral populations, which can be used to help determine if a given genetic variant is causal. We demonstrate the usefulness of the method on data from the Greenlandic population.

Download full-text PDF

Source
http://dx.doi.org/10.1002/gepi.22200DOI Listing
July 2019
1 Read

Publication Analysis

Top Keywords

admixed populations
12
association studies
8
genome-wide association
8
association testing
8
genetic variant
8
genetic variants
8
causal variant
8
ancestral populations
8
populations
5
populations size
4
testing admixed
4
method association
4
method
4
statistical method
4
size allowed
4
depend ancestry
4
method rely
4
rely accurate
4
allele method
4
ancestry allele
4

References

(Supplied by CrossRef)

Similar Publications