Is there a link between stress and immune biomarkers and salivary opiorphin in patients with a restrictive-type of anorexia nervosa?

World J Biol Psychiatry 2019 Mar 18:1-10. Epub 2019 Mar 18.

e Department of Psychiatry , Psychiatric Genetics Unit, PUMS , Poznań , Poland.

Objectives: Opiorphin is a salivary peptide with analgesic and antidepressant properties. Its relationship with the hypothalamic-pituitary-adrenal, autonomic nervous and immune systems may provide understanding of chronic stress, especially in anorexia nervosa (AN). This study investigated a possible correlation between opiorphin and stress/immune biomarkers, cortisol, salivary alpha-amylase (sAA) and secretory immunoglobulin A (sIgA), in saliva of patients with restrictive-type AN.

Methods: A case-control clinical trial was conducted in 92 AN patients (+75 healthy controls). Unstimulated salivary samples were taken during the acute stage of AN, measurements of cortisol, sAA, sIgA and opiorphin were performed with a quantitative assay (enzyme-linked immunosorbent assay, P < 0.05).

Results: AN patients displayed an increase in cortisol (P < 0.001) and sIgA (P < 0.001) but not in sAA (P = 0.279) levels. Distinct correlation between these two parameters and body-weight indexes were observed. Opiorphin levels were neither correlated to stress and immune biomarkers, nor to salivary flow rate.

Conclusions: The effect of stress responses can be reliably assessed in saliva in AN patients. The difference between sIgA and cortisol indicate that they can both be used for mental stress assessment in saliva. Modulation of opiorphin by chronic stress was not confirmed. Unchanged sAA indicates a partial adaptation of human organism to severe condition during malnutrition.

Download full-text PDF

Source
http://dx.doi.org/10.1080/15622975.2019.1593502DOI Listing
March 2019
9 Reads

Publication Analysis

Top Keywords

patients restrictive-type
8
immunoglobulin siga
4
secretory immunoglobulin
4
saa secretory
4
siga saliva
4
saliva patients
4
clinical trial
4
case-control clinical
4
anmethods case-control
4
restrictive-type anmethods
4
alpha-amylase saa
4
salivary alpha-amylase
4
nervosa study
4
anorexia nervosa
4
stress anorexia
4
chronic stress
4
study investigated
4
investigated correlation
4
cortisol salivary
4
biomarkers cortisol
4

References

(Supplied by CrossRef)

Bosch JA et al.
J Psychophysiol 1998

Similar Publications