Understanding sex differences in long-term blood pressure regulation: insights from experimental studies and computational modeling.

Authors:
Rui Hu
Rui Hu
University of Rochester
United States
Anita T Layton
Anita T Layton
Duke University
United States

Am J Physiol Heart Circ Physiol 2019 May 15;316(5):H1113-H1123. Epub 2019 Mar 15.

Department of Applied Mathematics, University of Waterloo , Waterloo, Ontario , Canada.

Sex differences in blood pressure and the prevalence of hypertension are found in humans and animal models. Moreover, there has been a recent explosion of data concerning sex differences in nitric oxide, the renin-angiotensin-aldosterone system, inflammation, and kidney function. These data have the potential to reveal the mechanisms underlying male-female differences in blood pressure control. To elucidate the interactions among the multitude of physiological processes involved, one may apply computational models. In this review, we describe published computational models that represent key players in blood pressure regulation, and highlight sex-specific models and their findings.

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Source
https://www.physiology.org/doi/10.1152/ajpheart.00035.2019
Publisher Site
http://dx.doi.org/10.1152/ajpheart.00035.2019DOI Listing
May 2019
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