The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies.

Int J Cancer 2019 Dec 4;145(12):3244-3256. Epub 2019 Apr 4.

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.32276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745281PMC
December 2019
27 Reads

Publication Analysis

Top Keywords

lower concentrations
24
igfbp-1 igfbp-2
24
concentrations igfbp-1
16
concentrations igf-i
16
igf-i igf-ii
16
higher concentrations
16
concentrations
14
sociodemographic factors
12
anthropometric behavioural
12
behavioural sociodemographic
12
circulating concentrations
12
associated higher
12
igfbp-2 igfbp-3
12
igfbp-2 lower
8
concentrations igfs
8
insulin-like growth
8
igf-ii igfbp-1
8
cancer risk
8
prostate cancer
8
igf-ii igfbp-3
8

References

(Supplied by CrossRef)

Similar Publications