CD163+ macrophages predict a poor prognosis in patients with primary T1 high-grade urothelial carcinoma of the bladder.

World J Urol 2019 Dec 13;37(12):2721-2726. Epub 2019 Mar 13.

Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Purpose: Macrophages are a major cell type that can infiltrate solid tumors and exhibit distinct phenotypes in different tumor microenvironments. This study investigates the prognostic value of tumor-infiltrated CD163+ macrophages in patients with T1 high-grade (T1HG) bladder cancer.

Methods: CD163+ macrophages were assessed by immunohistochemistry in 94 T1HG bladder cancer samples. Kaplan-Meier analyses and Cox proportional hazards' regression models were applied to evaluate recurrence-free survival, progression-free survival and disease-specific survival.

Results: With a median follow-up of 60 months, 37 (39.4%) patients experienced disease recurrence, 14 (14.9%) progression, 11 (11.7%) disease-specific mortality. High CD163+ macrophages were associated with higher risk of disease recurrence and progression (P < 0.05, for both). In multivariate Cox proportional hazards regression analysis, high CD163+ macrophages were a significant negative predictor of recurrence-free survival, progression-free survival and disease-specific survival (P < 0.05 for all).

Conclusion: CD163+ macrophages are a poor prognostic factor in T1HG bladder cancer. This finding provide the ground for further testing it in predicting the outcome of this challenging disease.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00345-018-02618-1DOI Listing
December 2019
1 Read

Publication Analysis

Top Keywords

cd163+ macrophages
16
t1hg bladder
8
disease recurrence
8
macrophages assessed
4
cancermethods cd163+
4
bladder cancermethods
4
assessed immunohistochemistry
4
bladder cancer
4
cd163+
4
immunohistochemistry t1hg
4
experienced disease
4
patients high-grade
4
recurrence 149%
4
disease-specific survivalresults
4
microenvironments study
4
149% progression
4
investigates prognostic
4
prognostic tumor-infiltrated
4
cancer samples
4
macrophages patients
4

Similar Publications