Family history of cancer, Ashkenazi Jewish ancestry, and pancreatic cancer risk.

Authors:
Tsuyoshi Hamada
Tsuyoshi Hamada
Graduate School of Medicine
Chen Yuan
Chen Yuan
Harvard School of Public Health
Matthew B Yurgelun
Matthew B Yurgelun
Dana-Farber Cancer Institute
Kimberly Perez
Kimberly Perez
Brown University Oncology Research Group
United States
Natalia Khalaf
Natalia Khalaf
Baylor College of Medicine
United States
Ana Babic
Ana Babic
Harvard T.H. Chan School of Public Health
United States
Jonathan A Nowak
Jonathan A Nowak
Howard Hughes Medical Institute

Br J Cancer 2019 Apr 14;120(8):848-854. Epub 2019 Mar 14.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.

Background: Individuals with a family history of cancer may be at increased risk of pancreatic cancer. Ashkenazi Jewish (AJ) individuals carry increased risk for pancreatic cancer and other cancer types.

Methods: We examined the association between family history of cancer, AJ heritage, and incident pancreatic cancer in 49 410 male participants of the prospective Health Professionals Follow-up Study. Hazard ratios (HRs) were estimated using multivariable-adjusted Cox proportional hazards models.

Results: During 1.1 million person-years (1986-2016), 452 participants developed pancreatic cancer. Increased risk of pancreatic cancer was observed in individuals with a family history of pancreatic (HR, 2.79; 95% confidence interval [CI], 1.28-6.07) or breast cancer (HR, 1.40; 95% CI, 1.01-1.94). There was a trend towards higher risk of pancreatic cancer in relation to a family history of colorectal cancer (HR, 1.21; 95% CI, 0.95-1.55) or AJ heritage (HR, 1.29; 95% CI, 0.94-1.77). The risk was highly elevated among AJ men with a family history of breast or colorectal cancer (HR, 2.61 [95% CI, 1.41-4.82] and 1.92 [95% CI, 1.05-3.49], respectively).

Conclusion: Family history of pancreatic cancer was associated with increased risk of this malignancy. Family history of breast or colorectal cancer was associated with the increased risk among AJ men.

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Source
http://www.nature.com/articles/s41416-019-0426-5
Publisher Site
http://dx.doi.org/10.1038/s41416-019-0426-5DOI Listing
April 2019
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