Follow-up of children with antenatally diagnosed idiopathic polyhydramnios.

Authors:
Magdalena Adamczyk
Magdalena Adamczyk
Cardiff University
United Kingdom
Jakub Kornacki
Jakub Kornacki
Poznań University of Medical Sciences
Poland
Przemyslaw Wirstlein
Przemyslaw Wirstlein
Poznań University of Medical Sciences
Poznań | Poland
Malgorzata Szczepanska
Malgorzata Szczepanska
Max Planck Institute for Molecular Genetics
Germany
Ewa Wender-Ozegowska
Ewa Wender-Ozegowska
Poznan University of Medical Sciences
Poland

Ginekol Pol 2019 ;90(2):93-99

Division of Reproduction, Department of Gynecology and Obstetrics, Poznan University of Medical Sciences, Poland.

Objectives: The aim of our work was to assess the development of children with antenatally diagnosed idiopathic poly- hydramnios, over 12 months from the end of pregnancy.

Material And Methods: The study included 91 healthy pregnant patients with idiopathic polyhydramnios. Diagnostic tests results and perinatal medical history were obtained retrospectively. Parents of children were contacted by phone and by mail. The answers were obtained from 64 (70%) parents. For statistical analysis SigmaStat3.5 software was used.

Results: Ninety six percent of parents declared that in their opinion the development of children was normal. Abnormali- ties were found in 44% of the children. Thirty percent of neonates demonstrated mild abnormalities which may be due to organic or functional neuromuscular disorders: abnormal muscle tone, speech apparatus and development disorders, swallowing and breathing problems (manifested as vomiting, excessive regurgitation, idiopathic apnoeas). Isolated small malformations were diagnosed in 12 (19%) children. Two children (3%) with SGA were diagnosed with genetic syndromes. More than one of the abnormalities described above were diagnosed in 14% of children. Gestational age at the time of polyhydramnios diagnosis and its severity were not prognostic factors for abnormalities. Seventy percent of newborns were male.

Conclusions: Despite the subjectively positive assessment of the development of children by the majority of parents, groups of common disorders requiring long-term follow-up have been identified. Functional disorders of the gastrointestinal tract, CNS and the group of neuromuscular disorders may be responsible for idiopathic polyhydramnios. SGA with co-existing idiopathic polyhydramnios is associated with the risk of genetic diseases. The more frequent incidence of idiopathic poly- hydramnios in male fetuses requires further research.

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Source
https://journals.viamedica.pl/ginekologia_polska/article/vie
Publisher Site
http://dx.doi.org/10.5603/GP.2019.0016DOI Listing
January 2019
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