Expression of Cripto-1 in the placenta and its role in placenta accreta and placenta previa.

Authors:
Lingling Jiang
Lingling Jiang
Hebei Medical University
China
Xiaoya Wu
Xiaoya Wu
Institute of Plant and Environment Protection
Jianying Yan
Jianying Yan
Lehigh University
United States
Rongxin Chen
Rongxin Chen
Liver Cancer Institute
China
Qing Han
Qing Han
School of Pharmacy
Lawrence | United States

Ginekol Pol 2019 ;90(2):86-92

Fujian Provincial Maternity and Children's Hospital, affiliated hospital of Fujian Medical University, Fuzhou, Fujian, China.

Objectives: This study Aims to explore the role of placental Cripto-1 in the incidence of an adherent placenta.

Material And Methods: Ten pregnant women with placenta increta, 20 pregnant women with placenta previa and 30 women with normal pregnant were enrolled in this study. Reverse transcription-polymerase chain reaction (RT-PCR) was used to measure the expression of Cripto-1 in the placenta while as the analysis of placental Cripto-1 was performed by Western blotting RESULTS: The placenta increta group showed higher levels of Cripto-1 in the center of the increta as compared to the non-implantation area. The level of placental Cripto-1 in the placenta increta was higher than that of the placenta accrete. The expression of placental Cripto-1 in the placenta increta and placenta previa groups was higher than that of control.

Conclusions: Placental Cripto-1 is involved in the regulation of placental tissue invasion. Additionally, excessive placental growth or penetration into the myometrium are likely to be involved in the development of placenta increta.

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Source
http://dx.doi.org/10.5603/GP.2019.0015DOI Listing
January 2019
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