[Meningococcal sepsis without cerebrospinal fluid abnormalities under treatment with eculizumab].

Authors:
Sebastian Schwind
Sebastian Schwind
The Ohio State University
United States
Vladan Vucinic
Vladan Vucinic
University of Leipzig
Germany
Sebastian Wendt
Sebastian Wendt
Charité Universitätsmedizin Berlin
Germany
Catalina-Suzana Stingu
Catalina-Suzana Stingu
University of Leipzig
Germany
Dietger Niederwieser
Dietger Niederwieser
University of Leipzig
Leipzig | Germany
Lorenz Weidhase
Lorenz Weidhase
Martin-Luther-Universität Halle-Wittenberg
Germany

Med Klin Intensivmed Notfmed 2019 Mar 8. Epub 2019 Mar 8.

Interdisziplinäre internistische Intensivstation, Universitätsklinikum Leipzig, Liebigstraße 20, 04103, Leipzig, Deutschland.

Infections with Neisseria meningitidis are life-threatening conditions, generally presenting as meningitis. This case of a young woman who had a history of paroxysmal nocturnal hemoglobinuria under treatment with the complement inhibitor eculizumab had been presented with septic shock. While blood cultures were positive for Neisseria meningitidis, she showed no evidence for bacterial meningitis in the cerebrospinal fluid. This case shows that meningococcal sepsis without signs for bacterial meningitis despite repetitive vaccinations is possible in adults under eculizumab.

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http://dx.doi.org/10.1007/s00063-019-0552-0DOI Listing
March 2019
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