Med Klin Intensivmed Notfmed 2019 Mar 8. Epub 2019 Mar 8.
Interdisziplinäre internistische Intensivstation, Universitätsklinikum Leipzig, Liebigstraße 20, 04103, Leipzig, Deutschland.
Infections with Neisseria meningitidis are life-threatening conditions, generally presenting as meningitis. This case of a young woman who had a history of paroxysmal nocturnal hemoglobinuria under treatment with the complement inhibitor eculizumab had been presented with septic shock. While blood cultures were positive for Neisseria meningitidis, she showed no evidence for bacterial meningitis in the cerebrospinal fluid. This case shows that meningococcal sepsis without signs for bacterial meningitis despite repetitive vaccinations is possible in adults under eculizumab.