Expression of soluble receptor for advanced glycation end products is associated with disease severity in congenital diaphragmatic hernia.

Am J Physiol Lung Cell Mol Physiol 2019 Jun 6;316(6):L1061-L1069. Epub 2019 Mar 6.

Institute for Clinical Chemistry and Clinical Pharmacology, University of Bonn , Bonn , Germany.

Pulmonary hypertension (PH) and lung hypoplasia are major contributors to morbidity and mortality in newborns with congenital diaphragmatic hernia (CDH). The soluble receptor for advanced glycation end products (sRAGE) is a marker of endothelial function and might be associated with disease severity in CDH newborns. In a cohort of 30 CDH newborns and 20 healthy control newborns, sRAGE concentration was measured at birth and at 6 h, 12 h, 24 h, 48 h, and 7-10 days. In healthy newborns, sRAGE was significantly higher at birth and at 48 h compared with CDH newborns (both < 0.001). Among CDH newborns, sRAGE was significantly lower at birth ( = 0.033) and at 7-10 days ( = 0.035) in patients receiving extracorporeal membrane oxygenation (ECMO) compared with patients not receiving ECMO. In contrast, CDH newborns receiving ECMO had significantly higher values at 6 h ( = 0.001), 12 h ( = 0.004), and 48 h (0.032). Additionally, sRAGE correlated significantly with PH severity, intensity and duration of mechanical ventilation, and prenatally assessed markers of CDH severity (lung size, liver herniation). The probability to receive ECMO therapy was five times higher in CDH newborns with sRAGE concentrations below the calculated cutoff of 650 pg/ml at birth ( = 0.002) and nine times higher in CDH newborns with sRAGE concentrations above the cutoff of 3,500 pg/ml at 6 h ( = 0.001). These findings suggest a potential involvement of sRAGE in the pathophysiology of CDH and may act as a therapeutic target in future treatment approaches.

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00359.2018DOI Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
June 2019
7 Reads

Publication Analysis

Top Keywords

cdh newborns
28
newborns srage
20
newborns
10
cdh
10
diaphragmatic hernia
8
7-10 days
8
congenital diaphragmatic
8
patients receiving
8
srage concentrations
8
higher cdh
8
srage
8
soluble receptor
8
times higher
8
disease severity
8
receiving ecmo
8
receptor advanced
8
advanced glycation
8
glycation products
8
associated disease
8
srage lower
4

Similar Publications