meningitis in a Saudi infant: case report and literature review.

Authors:
Mohammed A Alshehri
Mohammed A Alshehri
College of Medicine
Tariq S AlFawaz
Tariq S AlFawaz
The Rockefeller University
United States
Maqsood Ahmad
Maqsood Ahmad
School of Pharmaceutical Sciences
Malaysia
Dayel A Alshahrani
Dayel A Alshahrani
Children's Hospital
Saudi Arabia

Int J Pediatr Adolesc Med 2018 Sep 18;5(3):122-126. Epub 2018 Sep 18.

Children Specialized Hospital, King Fahad Medical City, Saudi Arabia.

Background: Anaerobic meningitis is mainly caused by and it is rarely detected in children. Few cases have been reported and there is usually an underlying cause. The timing of early recognition is crucial because any delay in the diagnosis and initiation of appropriate antimicrobial therapy has a devastating outcome. Only 14 cases have been reported in 50 years. To the best of our knowledge, the present case is the first to be reported in Saudi Arabia with no underlying etiology.

Case Presentation: We describe a 35-day-old male infant with culture-negative pyogenic meningitis who did not show satisfactory response to the empirical antibiotics, consequently, he developed severe subdural/epidural empyema and ventriculitis. When the drained empyema was cultured anaerobically, was detected and the patient improved after treatment with metronidazole combined with adjuvant surgical drainage of the empyema, and he finally had hydrocephalus. No underlying etiology was found to explain his infection.

Conclusion: is an uncommon cause of meningitis that requires a high index of clinical suspicion. Any pyogenic cerebrospinal fluid with negative culture should draw the attention of physicians to an unusual organisms such as anaerobes because early identification and initiation of appropriate antimicrobials can prevent long-term morbidity and mortality.

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Source
http://dx.doi.org/10.1016/j.ijpam.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363260PMC
September 2018
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