Implementation of a practical and effective pilot intervention against transmission of Taenia solium by pigs in the Banke district of Nepal.

Authors:
Dr. Ishab Poudel
Dr. Ishab Poudel
Heifer International
kathmandu | Nepal
Keshav Sah
Keshav Sah
Heifer International
Little Rock | United States
Suyog Subedi
Suyog Subedi
Heifer International
Little Rock | United States
Dinesh Kumar Singh
Dinesh Kumar Singh
Banaras Hindu University
India
Peetambar Kushwaha
Peetambar Kushwaha
GALVmed
United Kingdom
Angela Colston
Angela Colston
University of Strathclyde
United Kingdom
Charles G Gauci
Charles G Gauci
The University of Melbourne
Australia
Meritxell Donadeu
Meritxell Donadeu
Campus Universitario
Argentina

PLoS Negl Trop Dis 2019 02 25;13(2):e0006838. Epub 2019 Feb 25.

Veterinary Clinical Centre, Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Werribee Victoria, Australia.

Taenia solium is a zoonotic cestode parasite which causes human neurocysticercosis. Pigs transmit the parasite by acting as the intermediate host. An intervention was implemented to control transmission of T. solium by pigs in Dalit communities of Banke District, Nepal. Every 3 months, pigs were vaccinated with the TSOL18 recombinant vaccine (Cysvax, IIL, India)) and, at the same time, given an oral treatment with 30mg/kg oxfendazole (Paranthic 10% MCI, Morocco). The prevalence of porcine cysticercosis was determined in both an intervention area as well as a similar no intervention control area, among randomly selected, slaughter-age pigs. Post mortem assessments were undertaken both at the start and at the end of the intervention. Participants conducting the post mortem assessments were blinded as to the source of the animals being assessed. At the start of the intervention the prevalence of porcine cysticercosis was 23.6% and 34.5% in the control and intervention areas, respectively. Following the intervention, the prevalence of cysticercosis in pigs from the control area was 16.7% (no significant change), whereas no infection was detected after complete slicing of all muscle tissue and brain in animals from the intervention area (P = 0.004). These findings are discussed in relation to the feasibility and sustainability of T. solium control. The 3-monthly vaccination and drug treatment intervention in pigs used here is suggested as an effective and practical method for reducing T. solium transmission by pigs. The results suggest that applying the intervention over a period of years may ultimately reduce the number of tapeworm carriers and thereby the incidence of NCC.

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http://dx.doi.org/10.1371/journal.pntd.0006838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405169PMC

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February 2019
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References

(Supplied by CrossRef)
Potential eradicability of taeniasis and cysticercosis
PM Schantz et al.
Bull Pan Am Health Organ 1993
The burden of parasitic zoonoses in Nepal: a systematic review
B Devleesschauwer et al.
PLoS Negl Trop Dis 2014

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