Association of chronic enteropathy activity index, blood urea concentration, and risk of death in dogs with protein-losing enteropathy.

Authors:
Aarti Kathrani
Aarti Kathrani
University of London
United Kingdom
Edward J Hall
Edward J Hall
University of Bristol
United Kingdom

J Vet Intern Med 2019 Mar 19;33(2):536-543. Epub 2019 Feb 19.

Bristol Veterinary School, University of Bristol, Bristol, United Kingdom.

Background: Malnutrition is associated with increased risk of premature death in humans with inflammatory bowel disease.

Hypothesis/objective: To determine if historical, clinical, and laboratory markers of malnutrition in dogs at the time of histologic diagnosis of protein-losing enteropathy (PLE) caused by chronic enteropathy (CE) or lymphangiectasia are associated with increased risk of death.

Animals: Seventy-one client-owned dogs diagnosed with PLE.

Methods: The medical records were retrospectively searched for cases of PLE, diagnosed with CE or lymphangiectasia on the basis of histopathology of intestinal biopsies at a referral hospital. For each case, various variables at the time of diagnostic investigation were recorded and follow-up obtained by telephone contact with the referring veterinarian.

Results: A multivariable cox model indicated that canine chronic enteropathy activity index (CCEAI) and blood urea concentration were significantly associated with death (P values <.01). For each unit increase in CCEAI, the hazard of death increased by 22.9% (confidence interval [CI]: 6.9%-41.2%). Dogs with a CCEAI of ≤8 and dogs with urea ≤7 mmol/L survived 256 days longer (P = .001, CI: 106.7-405.4 days) and 279 days longer (P = .009, CI: 70.0-488.7 days) than those with a CCEAI of >8 and urea >7 mmol/L on average, respectively, when followed up for 647 days.

Conclusions And Clinical Importance: Increased CCEAI and blood urea concentration at the time of diagnosis might be predictive of death in dogs with PLE caused by CE or lymphangiectasia.

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Source
http://dx.doi.org/10.1111/jvim.15448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430906PMC
March 2019
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References

(Supplied by CrossRef)
Development and validation of a body condition score system for dogs
Laflamme D et al.
Canine Practice 1997

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