A multidimensional concept for mercury neuronal and sensory toxicity in fish - From toxicokinetics and biochemistry to morphometry and behavior.

Authors:
Patricia Pereira
Patricia Pereira
McGill University
Canada
Malgorzata Korbas
Malgorzata Korbas
University of Saskatchewan
Canada
Tiziana Cappello
Tiziana Cappello
University of Messina
Italy
Maria Maisano
Maria Maisano
University of Messina
Italy
Prof. Armando Almeida, PhD
Prof. Armando Almeida, PhD
University of Minho
Associate Professor
Pain, Neurosciences, Chronic Pain
Braga, xx | Portugal
Mario Pacheco
Mario Pacheco
Biochemistry and Biophysics Laboratory
Mexico

Biochim Biophys Acta Gen Subj 2019 Feb 12. Epub 2019 Feb 12.

Department of Biology and CESAM, University of Aveiro, Aveiro 3810-193, Portugal. Electronic address:

Background: Neuronal and sensory toxicity of mercury (Hg) compounds has been largely investigated in humans/mammals with a focus on public health, while research in fish is less prolific and dispersed by different species. Well-established premises for mammals have been governing fish research, but some contradictory findings suggest that knowledge translation between these animal groups needs prudence [e.g. the relative higher neurotoxicity of methylmercury (MeHg) vs. inorganic Hg (iHg)]. Biochemical/physiological differences between the groups (e.g. higher brain regeneration in fish) may determine distinct patterns. This review undertakes the challenge of identifying sensitive cellular targets, Hg-driven biochemical/physiological vulnerabilities in fish, while discriminating specificities for Hg forms.

Scope Of Review: A functional neuroanatomical perspective was conceived, comprising: (i) Hg occurrence in the aquatic environment; (ii) toxicokinetics on central nervous system (CNS)/sensory organs; (iii) effects on neurotransmission; (iv) biochemical/physiological effects on CNS/sensory organs; (v) morpho-structural changes on CNS/sensory organs; (vi) behavioral effects. The literature was also analyzed to generate a multidimensional conceptualization translated into a Rubik's Cube where key factors/processes were proposed.

Major Conclusions: Hg neurosensory toxicity was unequivocally demonstrated. Some correspondence with toxicity mechanisms described for mammals (mainly at biochemical level) was identified. Although the research has been dispersed by numerous fish species, 29 key factors/processes were pinpointed.

General Significance: Future trends were identified and translated into 25 factors/processes to be addressed. Unveiling the neurosensory toxicity of Hg in fish has a major motivation of protecting ichtyopopulations and ecosystems, but can also provide fundamental knowledge to the field of human neurodevelopment.

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http://dx.doi.org/10.1016/j.bbagen.2019.01.020DOI Listing
February 2019
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