Circulating inflammation markers and colorectal adenoma risk.

Carcinogenesis 2019 Jul;40(6):765-770

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

Inflammation is a driver of colorectal neoplasia; however, what particular inflammatory processes play a role in early carcinogenesis are unclear. We compared serum levels of 78 inflammation markers between 171 pathologically confirmed colorectal adenoma cases (including 48 incident cases) and 344 controls within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. We used weighted multivariable logistic regression to compute odds ratio (OR) and 95% confidence interval (CI). We found 14 markers associated with risk of adenoma overall; three of these were also associated with incident adenoma: CC-chemokine cysteine motif chemokine ligand 20 (CCL20) [overall adenoma fourth versus first quartile: OR 4.8, 95% CI 2.0-12, Ptrend 0.0007; incident adenoma third versus first tertile: OR 4.6, 95% CI 1.0-22, Ptrend 0.03], growth-related gene oncogene products (GRO) [OR 3.8, 95% CI 1.6-9.3, Ptrend 0.006 and OR 3.6, 95% CI 1.1-12, Ptrend 0.04, respectively] and insulin [OR 2.9, 95% CI 0.8-10, Ptrend 0.05 and OR 7.8, 95% CI 1.3-46, Ptrend 0.03, respectively]. All statistical tests were two-sided. These results provide important new evidence implicating CCL20- and GRO-related pathways in early colorectal carcinogenesis and further support a role for insulin.

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgz027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612053PMC
July 2019
20 Reads

Publication Analysis

Top Keywords

[or 95%
8
incident adenoma
8
inflammation markers
8
colorectal adenoma
8
95%
7
ptrend
6
adenoma
6
colorectal
5
20-12 ptrend
4
ptrend 00007
4
fourth versus
4
versus quartile
4
00007 incident
4
quartile 95%
4
95% 20-12
4
tertile 95%
4
10-22 ptrend
4
ptrend 003]
4
003] growth-related
4
95% 10-22
4

Similar Publications